2024
Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024 PMID: 39603869, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesSex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSS
2023
Sex differences in acute ischemic stroke presentation are a matter of infarct location
Higgins H, Chen L, Ravare B, Jeppson K, Bina H, Herson P, Monte A, Poisson S, Dylla L. Sex differences in acute ischemic stroke presentation are a matter of infarct location. The American Journal Of Emergency Medicine 2023, 74: 95-99. PMID: 37802001, PMCID: PMC10843056, DOI: 10.1016/j.ajem.2023.09.046.Peer-Reviewed Original ResearchConceptsEmergency medical servicesMultivariate logistic regressionStroke symptomsFrequency of patient presentationLogistic regressionStroke screening toolElectronic health recordsRecognition of strokeAcute ischemic strokeInfarct locationClassic symptomsEmergency department treatmentDistribution of strokeIschemic strokeIschemic stroke presentingHealth recordsRetrospective cohort studyMedical servicesUnilateral weaknessAnterior circulation infarctionCohort studyScreening toolStroke presentationEtiology of strokePosterior circulation infarction
2022
Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review
Dylla L, Higgins H, Piper C, Poisson S, Herson P, Monte A. Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review. Frontiers In Neurology 2022, 13: 1026431. PMID: 36504643, PMCID: PMC9729945, DOI: 10.3389/fneur.2022.1026431.Peer-Reviewed Original ResearchResponse to acute ischemic strokeAcute ischemic strokeIschemic strokeSystematic reviewNeurological outcomePathophysiology of acute ischemic strokePreclinical rat modelClinical cohort studyFull-text reviewNational Institutes of Health (NIHWeb of ScienceAcute stroke researchClinical research studiesSubgroup analysisCohort studyRat modelBiological variablesResearch studiesSex differencesSex-based differencesOvid MEDLINEStudy designLifetime morbidityMetabolic changesPatient outcomes