2010
Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD
Manuelidis L. Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. Journal Of NeuroVirology 2010, 17: 131-145. PMID: 21165784, DOI: 10.1007/s13365-010-0007-0.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacterAmino Acid SequenceAnimalsBase SequenceBrainConserved SequenceCreutzfeldt-Jakob SyndromeCricetinaeDeoxyribonucleasesDNA HelicasesDNA, CircularDNA, MitochondrialDNA-Directed DNA PolymeraseElectrophoresis, Agar GelGenome, BacterialHumansMiceMolecular Sequence DataNeuroblastomaNeurodegenerative DiseasesPlasmidsPolymerase Chain ReactionPrionsScrapieTumor Cells, CulturedTransmissible encephalopathy agents
Manuelidis L. Transmissible encephalopathy agents. Virulence 2010, 1: 101-104. PMID: 21178425, PMCID: PMC3073180, DOI: 10.4161/viru.1.2.10822.Peer-Reviewed Original ResearchConceptsTransmissible spongiform encephalopathiesKuru agentNormal miceRecent transmissionInfectious agentsTissue pathologyTSE agentsDisease latencyVirulence characteristicsNeural cellsSpongiform encephalopathiesPrion hypothesisEpidemic spreadAgentsGeographic regionsEncephalopathyVirulenceSuperinfectionMicePathology
1997
Beneath the emperor's clothes: The body of data in scrapie and CJD
Manuelidis L. Beneath the emperor's clothes: The body of data in scrapie and CJD. Annales De L Institut Pasteur / Actualités 1997, 8: 311-326. DOI: 10.1016/s0924-4204(97)86597-3.Peer-Reviewed Original Research
1983
Scrapie-associated fibrils in Creutzfeldt–Jakob disease
Merz P, Somerville R, Wisniewski H, Manuelidis L, Manuelidis E. Scrapie-associated fibrils in Creutzfeldt–Jakob disease. Nature 1983, 306: 474-476. PMID: 6358899, DOI: 10.1038/306474a0.Peer-Reviewed Original ResearchConceptsScrapie associated fibrilsCreutzfeldt-Jakob diseaseCentral nervous systemTitre of infectivityScrapie of sheepInfected brainPathological responseProgressive degenerationNervous systemSynaptosomal preparationsInfectious agentsBrain fractionsTransmissible encephalopathiesDiseaseHuman casesSpleen extractsAbnormal fibrilsSusceptible hostsScrapieClose associationDifferent tissuesEncephalopathyAgentsDegenerationTitres