2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsInvestigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus
Osmani L, Shin MS, Cai H, Lee SJ, Kim H, Yoo J, You S, Li C, Dong MX, Gomez-Villalobos J, Bucala R, Kang I. Investigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus. Single Cell Analyses conference at Cold Spring Harbor Laboratory. Nov 2023. Cold Spring Harbor, NY.Peer-Reviewed Original Research
2021
204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease
Osmani L, Pettus J, Roy A, Skopelja-Gardner S. 204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease. Lupus Science & Medicine 2021, 8: a5-a5. DOI: 10.1136/lupus-2021-lupus21century.8.Peer-Reviewed Original ResearchConcurrent skin diseasesHigher neutrophil countLupus nephritisSkin rashLN flareSkin diseasesSkin inflammationHigh neutrophilLN patientsLupus patientsNeutrophil countLupus nephritis biopsiesNeutrophil-lymphocyte ratioWorse kidney functionOnly female patientsRole of neutrophilsAnti-dsDNA IgGActivation of neutrophilsT-testStudent's t-testRenal inflammatoryActive diseaseKidney injuryChart reviewIgA deposition
2019
Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses
Rodriguez EF, Pastorello R, Osmani L, Hopkins M, Kryatova M, Kawamoto S, Maleki Z. Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses. Acta Cytologica 2019, 64: 208-215. PMID: 31362293, DOI: 10.1159/000501421.Peer-Reviewed Original ResearchConceptsLung massPulmonary adenocarcinomaMedical recordsTransthoracic fine needle aspirationConcurrent core biopsyAdvanced stage diseaseInstitutional review board approvalMajority of patientsTransthoracic needle aspirationCarcinoma/adenocarcinomaPatients' medical recordsFine-needle aspirationReview board approvalStage diseaseCommon diagnosisMean agePulmonary lesionsCore biopsyMalignant diagnosisNeedle aspirationPrior historyCytologic diagnosisInvasive proceduresBoard approvalCytology specimens
2017
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy
Osmani L, Askin F, Gabrielson E, Li QK. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Seminars In Cancer Biology 2017, 52: 103-109. PMID: 29183778, PMCID: PMC5970946, DOI: 10.1016/j.semcancer.2017.11.019.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaLung cancerWorld Health OrganizationLung carcinomaSignificant prognostic impactLung cancer patientsRecent large-scale genomic studiesSmall biopsy specimensDriver gene mutationsPrognostic impactCancer patientsBiopsy specimensTargeted therapyOncologic practiceAccurate subclassificationIHC biomarkersImmunohistochemical markersPatient careAccurate diagnosisImmunotherapyTherapyCancerSubclassificationCritical roleCurrent insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Ansari AM, Osmani L, Matsangos AE, Li QK. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis. Pathology - Research And Practice 2017, 213: 1237-1241. PMID: 28935176, DOI: 10.1016/j.prp.2017.08.013.Peer-Reviewed Original ResearchConceptsInsulin-derived amyloidosisSystemic amyloidosisDiabetic patientsGlycemic controlDifferential diagnosisAccurate diagnosisAggressive systemic therapyBlood glycemic controlCommon side effectsCase series studyClinico-pathological characteristicsNon-surgical approachSubcutaneous insulin injectionsPrimary cutaneous amyloidosisAnti-insulin antibodiesAutonomic neuropathyInsulin requirementsClinical suspicionKey diagnostic featuresRare complicationSystemic therapySurgical excisionSurgical interventionCase reportInsulin injectionsBiomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects
Osmani L, Li QK. Biomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects. Biomarkers In Medicine 2017, 11: 405-407. PMID: 28621614, DOI: 10.2217/bmm-2017-0059.Peer-Reviewed Original Research
2013
The COMBREX Project: Design, Methodology, and Initial Results
Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S. The COMBREX Project: Design, Methodology, and Initial Results. PLOS Biology 2013, 11: e1001638. PMID: 24013487, PMCID: PMC3754883, DOI: 10.1371/journal.pbio.1001638.Peer-Reviewed Original Research
2012
Thousands of missed genes found in bacterial genomes and their analysis with COMBREX
Wood DE, Lin H, Levy-Moonshine A, Swaminathan R, Chang YC, Anton BP, Osmani L, Steffen M, Kasif S, Salzberg SL. Thousands of missed genes found in bacterial genomes and their analysis with COMBREX. Biology Direct 2012, 7: 37. PMID: 23111013, PMCID: PMC3534567, DOI: 10.1186/1745-6150-7-37.Peer-Reviewed Original ResearchConceptsProtein-coding genesProkaryotic genome annotationCost of sequencingGenome annotationHypothetical proteinsBacterial genomesProkaryotic genomesShort genesArcady MushegianLikely geneGenesPhenotype informationGenomeHomologPotential targetPathogenic organismsAnnotationSequencingProteinFunction databaseAnnotation methodDramatic reductionGenBankOrganismsPharmaceutical research
2010
COMBREX: a project to accelerate the functional annotation of prokaryotic genomes
Roberts RJ, Chang YC, Hu Z, Rachlin JN, Anton BP, Pokrzywa RM, Choi HP, Faller LL, Guleria J, Housman G, Klitgord N, Mazumdar V, McGettrick MG, Osmani L, Swaminathan R, Tao KR, Letovsky S, Vitkup D, Segrè D, Salzberg SL, Delisi C, Steffen M, Kasif S. COMBREX: a project to accelerate the functional annotation of prokaryotic genomes. Nucleic Acids Research 2010, 39: d11-d14. PMID: 21097892, PMCID: PMC3013729, DOI: 10.1093/nar/gkq1168.Peer-Reviewed Original Research