2024
Classification of Human Ovarian Follicle Morphology: Recommendations of the NICHD-Sponsored Ovarian Nomenclature Workshop
Yano Maher J, Zelinski M, Oktay K, Duncan F, Segars J, Lujan M, Lou H, Yun B, Hanfling S, Schwartz L, Laronda M, Halvorson L, O'Neill K, Gomez-Lobo V. Classification of Human Ovarian Follicle Morphology: Recommendations of the NICHD-Sponsored Ovarian Nomenclature Workshop. Fertility And Sterility 2024 PMID: 39549739, DOI: 10.1016/j.fertnstert.2024.11.016.Peer-Reviewed Original ResearchPreantral folliclesAntral folliclesWorking subgroupEunice Kennedy Shriver National Institute of Child HealthNormal antral folliclesAntral follicle stageNational Institute of Child HealthInstitute of Child HealthPre-ovulatory folliclesPreantral stageAbnormal oocytesFollicle stageGranulosa cellsCorpora luteaFolliclesFollicle typesHuman fertilitySubgroupsFollicle densityAssessed changesCliniciansChild healthNICHDGranulosaOvarianPharmacological and Surgical Strategies to Improve Cryopreserved Ovarian Tissue Transplantation Longevity and Outcomes
Erden M, Oktay K. Pharmacological and Surgical Strategies to Improve Cryopreserved Ovarian Tissue Transplantation Longevity and Outcomes. Fertility And Sterility 2024 PMID: 39510240, DOI: 10.1016/j.fertnstert.2024.10.049.Peer-Reviewed Original ResearchTrends and regional differences for fertility preservation procedures in women with breast cancer
Turan V, Bedoschi G, Lee D, Barbosa C, de Oliveira R, Sacinti K, Sonmezer M, Lambertini M, Massarotti C, Schaub A, Wang E, Gayete-Lafuente S, Dunlop C, Anderson R, Bang H, Oktay K. Trends and regional differences for fertility preservation procedures in women with breast cancer. Clinical Breast Cancer 2024 PMID: 39428290, DOI: 10.1016/j.clbc.2024.09.011.Peer-Reviewed Original ResearchWomen of reproductive ageFertility preservationBreast cancerTissue cryopreservationYoung womenReproductive ageOvarian tissue cryopreservationFertility preservation methodsNormal ovarian functionOvarian stimulation cyclesFertility preservation proceduresFertility preservation practicesDiagnosed breast cancerOocyte cryopreservationOvarian stimulationTertiary centerMulticenter studyOvarian functionStimulated cyclesParticipating centersRegional time trendsBreastCancerPreservation proceduresChemotherapyUtility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers
Erden M, Gayete-Lafuente S, Vural N, Oktay K. Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers. Obstetrics And Gynecology 2024, 144: 481-492. PMID: 39173181, PMCID: PMC11499045, DOI: 10.1097/aog.0000000000005708.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue cryopreservationOvarian tissue transplantationTissue cryopreservationAutologous transplantationGynecologic cancerTissue transplantationOutcome of autologous transplantationPreserving ovarian functionCochrane Library databasesOvarian endocrine functionPooled-effect estimatesSystematic reviewRisk-of-bias assessmentOvarian stimulationHematologic malignanciesLonger-term outcomesFertility preservationOvarian functionBreast cancerLibrary databasesTransplantationGraft longevityCancerEndocrine functionP-360 Autologous cryopreserved ovarian tissue transplantation and perinatal outcomes: a systematic review with pooled analysis
Erden M, Uyanik E, Demeestere I, Oktay K. P-360 Autologous cryopreserved ovarian tissue transplantation and perinatal outcomes: a systematic review with pooled analysis. Human Reproduction 2024, 39: deae108.073. DOI: 10.1093/humrep/deae108.073.Peer-Reviewed Original ResearchOvarian tissue cryopreservationCryopreserved ovarian tissue transplantationOvarian tissue transplantationPerinatal outcomesPre-eclampsiaComplication ratePerinatal complicationsLive birthsPreterm premature rupture of membranesIncidence of gestational diabetes mellitusPerinatal outcomes of babiesLarge-for-gestational-agePremature rupture of membranesHypertensive disorders of pregnancyLong-term follow-up dataPerinatal complication ratePre-eclampsia incidencePreterm premature ruptureTissue transplantationRupture of membranesDisorders of pregnancyOutcomes of babiesPregnancy-induced hypertensionGeneral pregnant populationPreterm birth rateThe role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Suzuki R, Tan X, Szymanska K, Kubikova N, Perez C, Wells D, Oktay K. The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging. Cell Death Discovery 2024, 10: 302. PMID: 38914566, PMCID: PMC11196715, DOI: 10.1038/s41420-024-02041-z.Peer-Reviewed Original ResearchOocyte qualityAtaxia telangiectasia-mutatedOocyte agingMaintenance of oocyte qualityDNA double-strand breaksMeiosis in vitroPoor embryo developmentImpaired oocyte qualityATM functionMolecular cytogenetic analysisFormation of DNA DSBsDeath compared to controlsBlastocyst stageEmbryo cleavageDNA DSBsOvarian agingCytogenetic analysisResistance to genotoxic stressActive metaboliteNext-generation sequencingRates compared to controlsIn vitro cultureOocytesDNA DSB repairAge-induced declineOnset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study
Loggers E, Chugh R, Federman N, Hartner L, Riedel R, Cho S, Hyslop D, Lim A, Oton A, Oktay K. Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study. Cancer 2024, 130: 2812-2821. PMID: 38703010, DOI: 10.1002/cncr.35324.Peer-Reviewed Original ResearchFemales of reproductive potentialFollicle-stimulating hormoneReturn of menstruationOvarian toxicityDesmoid tumorsFollow-upContinuous 28-day cyclesLost to follow-upPhase 3 studyProgressive desmoid tumorsPost hoc analysisSafety populationNirogacestatStopping treatmentHormone valuesSafety signalsHoc analysisPatientsPerimenopausal symptomsMenstruationGamma-secretase inhibitorsPlaceboRandom femalesTumorEvent follow-upPerinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis
Erden M, Uyanik E, Demeestere I, Oktay K. Perinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis. American Journal Of Obstetrics And Gynecology 2024, 231: 480-489. PMID: 38621483, PMCID: PMC11473709, DOI: 10.1016/j.ajog.2024.04.012.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue transplantationPerinatal complication rateOvarian tissue cryopreservationPerinatal outcomesGestational ageAssisted reproductive techniquesPre-eclampsiaTissue transplantationTissue cryopreservationComplication rateIncidence of gestational diabetesLarge-for-gestational-agePreterm premature rupture of membranesIncidence of gestational diabetes mellitusPerinatal outcomes of pregnanciesPremature rupture of membranesHypertensive disorders of pregnancyReproductive techniquesPre-eclampsia incidenceObservational studyPreterm premature ruptureRupture of membranesComprehensive search of MEDLINEDisorders of pregnancy895 The utility, safety and outcomes of ovarian tissue cryopreservation for gynecologic cancers: an analysis from a large fertility preservation program and systematic review of the literature
Erden M, Gayete-Lafuente S, Vural N, Oktay K. 895 The utility, safety and outcomes of ovarian tissue cryopreservation for gynecologic cancers: an analysis from a large fertility preservation program and systematic review of the literature. 2024, a243.2-a244. DOI: 10.1136/ijgc-2024-esgo.473.Peer-Reviewed Original ResearchTo the editor: patient selection for ovarian tissue cryopreservation: should there be a strict age limit?
Marin L, Pacheco F, Oktay K. To the editor: patient selection for ovarian tissue cryopreservation: should there be a strict age limit? Fertility And Sterility 2024, 121: 894-895. PMID: 38346551, DOI: 10.1016/j.fertnstert.2024.02.007.Peer-Reviewed Original ResearchModeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvestFemale Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
2022
OOCYTE CRYOPRESERVATION WITH IN VITRO MATURATION, A FEASIBLE OPTION FOR FERTILITY PRESERVATION IN ADOLESCENTS WITH MOSAIC TURNER SYNDROME
Lafuente S, Turan V, Oktay K. OOCYTE CRYOPRESERVATION WITH IN VITRO MATURATION, A FEASIBLE OPTION FOR FERTILITY PRESERVATION IN ADOLESCENTS WITH MOSAIC TURNER SYNDROME. Fertility And Sterility 2022, 118: e69. DOI: 10.1016/j.fertnstert.2022.08.214.Peer-Reviewed Original ResearchIS IT SAFE TO PERFORM OVARIAN CRYOPRESERVATION AND TRANSPLANTATION IN PATIENTS WITH LEUKEMIA A 5-YEAR SURVIVAL ANALYSIS DATA
Sonmezer M, Sükür Y, Saçinti K, Ozkavukcu S, Kankaya D, Seval G, Atabekoglu C, Oktay K. IS IT SAFE TO PERFORM OVARIAN CRYOPRESERVATION AND TRANSPLANTATION IN PATIENTS WITH LEUKEMIA A 5-YEAR SURVIVAL ANALYSIS DATA. Fertility And Sterility 2022, 118: e202. DOI: 10.1016/j.fertnstert.2022.08.575.Peer-Reviewed Original ResearchPRESENCE OF BRCA MUTATIONS AND A PRE-CHEMOTHERAPY AMH LEVEL OF < 2ng/ML STRONGLY PREDICT RISK OF AMENORRHEA IN WOMEN WITH BREAST CANCER
Oktay K, Turan V, Bedoschi G, Goldfarb S, Bang H. PRESENCE OF BRCA MUTATIONS AND A PRE-CHEMOTHERAPY AMH LEVEL OF < 2ng/ML STRONGLY PREDICT RISK OF AMENORRHEA IN WOMEN WITH BREAST CANCER. Fertility And Sterility 2022, 118: e231. DOI: 10.1016/j.fertnstert.2022.08.652.Peer-Reviewed Original ResearchAnatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm
O'Neill KE, Maher JY, Laronda MM, Duncan FE, LeDuc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL, Zelinski MB, Halvorson LM, Gomez-Lobo V. Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm. American Journal Of Obstetrics And Gynecology 2022, 228: 270-275.e4. PMID: 36191605, PMCID: PMC9974561, DOI: 10.1016/j.ajog.2022.09.040.Peer-Reviewed Original ResearchLaparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderImpact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal?
Oktay K, Marin L, Titus S. Impact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal? Fertility And Sterility 2022, 117: 396-398. PMID: 34998576, DOI: 10.1016/j.fertnstert.2021.12.007.Peer-Reviewed Original ResearchFertility Preservation in Breast Cancer Patients
Marin L, Turan V, Oktay K. Fertility Preservation in Breast Cancer Patients. 2022, 185-198. DOI: 10.1007/978-3-030-47767-7_14.Peer-Reviewed Original ResearchFertility preservation issuesBreast cancerGonadotropin-releasing hormone agonistNovel chemotherapy regimensSafety of pregnancyFertility preservation techniquesBreast cancer survivorsBreast cancer patientsBreast cancer survivalPremature ovarian insufficiencyBreast cancer treatmentChemotherapy regimensOvarian suppressionPremenopausal womenOvarian reserveHormone agonistCancer survivorsCommon malignancyFertility preservationOvarian functionCancer patientsCancer survivalBRCA mutationsSexual dysfunctionFertility risksFemale Infertility
Oktay K, Taylan E. Female Infertility. 2022, 1376-1381. DOI: 10.1093/med/9780198870197.003.0165.Peer-Reviewed Original ResearchFertility preservationOvarian insufficiencyOvarian follicle reservePreservation of fertilityReproductive-age womenEffective treatment optionOvarian endocrine functionAntineoplastic treatmentSurgical interventionFollicle reserveTreatment optionsAge womenFemale infertilityEndocrine functionPsychosocial healthChromosomal disordersReproductive technologiesWomenImproved qualityModern healthcareIrreversible lossInfertilityInsufficiency