2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisDNA DamageFemaleFertility PreservationHumansOvarian FollicleOvarian ReserveOvaryConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2009
Fertility Preservation for Breast Cancer Patients
Oktem O, Oktay K. Fertility Preservation for Breast Cancer Patients. Seminars In Reproductive Medicine 2009, 27: 486-492. PMID: 19806518, DOI: 10.1055/s-0029-1241059.Peer-Reviewed Original ResearchConceptsBreast cancer patientsOvarian stimulation protocolsCancer patientsBreast cancerFertility preservationCancer survivorsStimulation protocolConventional ovarian stimulation protocolsRise of estrogenOvarian tissue freezingBreast cancer survivorsPreservation of fertilityEndogenous estrogen levelsFertility preservation strategiesAromatase inhibitor letrozolePremature ovarian failureNew cancer casesAdjuvant chemotherapyOvarian stimulationFertilization cyclesEstrogen levelsOvarian failureOocyte freezingReproductive ageCommon neoplasm
2002
Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips
Oktay K, Yih M. Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips. Seminars In Reproductive Medicine 2002, 20: 063-074. PMID: 11941536, DOI: 10.1055/s-2002-23520.Peer-Reviewed Original ResearchConceptsOvarian cortical stripsOvarian transplantationOvarian tissueCortical stripsHeterotopic transplantationAutologous ovarian transplantationFrozen ovarian tissueHeterotopic techniqueNew York surgeonPatient selectionOvarian functionSurgical techniqueTransplantationTransplanted tissuePreliminary experienceExperimental modelOperating roomCancer cellsClinical applicationTissueSafety measuresOrthotopicCliniciansSurgeonsTrounson