2002
The potential of ovarian tissue transplant to preserve fertility
Buyuk E, Oktay K. The potential of ovarian tissue transplant to preserve fertility. Expert Opinion On Biological Therapy 2002, 2: 361-370. PMID: 11955275, DOI: 10.1517/14712598.2.4.361.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleFertilityHumansInfertility, FemaleOvarian NeoplasmsOvaryTransplantation, AutologousTransplantation, HeterologousConceptsClinical studiesOvarian tissue transplantsSafety of pregnancyFuture clinical trialsPremature ovarian failureOvarian follicle developmentOvarian graftsOvarian cryopreservationOvarian transplantationOvarian functionCancer patientsOvarian failureClinical trialsAnimal studiesTissue transplantsOvarian tissueFurther basic researchHormone productionFollicle developmentRevascularisation processPregnancyPatientsTransplantationWomenSafety
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCryopreservationFemaleHumansInfertilityMiceMice, SCIDNeoplasmsOvaryPregnancySheepTransplantation, HeterologousConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomen
2000
Ovarian cryopreservation and transplantation: basic aspects
Oktay K, Karlikaya G, Aydin B. Ovarian cryopreservation and transplantation: basic aspects. Molecular And Cellular Endocrinology 2000, 169: 105-108. PMID: 11155939, DOI: 10.1016/s0303-7207(00)00361-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsClinical Trials as TopicCryopreservationFemaleHumansModels, AnimalOvaryPregnancyTransplantation, HeterologousTransplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice
Oktay K, Newton H, Gosden R. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertility And Sterility 2000, 73: 599-603. PMID: 10689020, DOI: 10.1016/s0015-0282(99)00548-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCryopreservationFemaleHumansMiceMice, SCIDOvarian FollicleOvaryTransplantation, HeterologousConceptsOvarian tissueSCID miceFrozen-thawed human ovarian tissueFrozen-thawed ovarian tissueAutologous ovarian transplantationFrozen-thawed graftsHuman ovarian tissueFollicle growth initiationLong-term survivalWeeks of graftingHuman primordial folliclesFollicle countOvarian transplantationImmunodeficiency miceMAIN OUTCOMEHealthy folliclesPrimordial folliclesAcademic centersAnimal studiesFollicle stageAdvanced folliclesFolliclesGraftMiceNecrotic cells
1998
Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone.
Oktay K, Newton H, Mullan J, Gosden R. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Human Reproduction 1998, 13: 1133-1138. PMID: 9647533, DOI: 10.1093/humrep/13.5.1133.Peer-Reviewed Original ResearchConceptsWeeks of graftingSevere combined immunodeficiencyFollicle growthOvarian xenograftsAntral stageOestradiol levelsLong-term graftHuman ovarian xenograftsHuman follicle developmentHuman ovarian tissueOvarian follicular growthPreantral follicle growthLong-term graftingGranulosa cell layerHuman primordial folliclesCell nuclear antigenFSH administrationHpg miceKidney capsuleGonadotrophin stimulationRenal capsuleHuman ovaryImmunodeficient miceFollicular growthSmall follicles