2024
Trends and regional differences for fertility preservation procedures in women with breast cancer
Turan V, Bedoschi G, Lee D, Barbosa C, de Oliveira R, Sacinti K, Sonmezer M, Lambertini M, Massarotti C, Schaub A, Wang E, Gayete-Lafuente S, Dunlop C, Anderson R, Bang H, Oktay K. Trends and regional differences for fertility preservation procedures in women with breast cancer. Clinical Breast Cancer 2024 PMID: 39428290, DOI: 10.1016/j.clbc.2024.09.011.Peer-Reviewed Original ResearchWomen of reproductive ageFertility preservationBreast cancerTissue cryopreservationYoung womenReproductive ageOvarian tissue cryopreservationFertility preservation methodsNormal ovarian functionOvarian stimulation cyclesFertility preservation proceduresFertility preservation practicesDiagnosed breast cancerOocyte cryopreservationOvarian stimulationTertiary centerMulticenter studyOvarian functionStimulated cyclesParticipating centersRegional time trendsBreastCancerPreservation proceduresChemotherapy
2021
Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data
Turan V, Lambertini M, Lee D, Wang E, Clatot F, Karlan B, Demeestere I, Bang H, Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. Journal Of Clinical Oncology 2021, 39: 2016-2024. PMID: 33891474, PMCID: PMC8260903, DOI: 10.1200/jco.20.02880.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataSerum AMH levelsDiminished ovarian reservePatient-level dataAMH levelsOvarian reservePathogenic variantsGermline BRCA pathogenic variantLow serum AMH levelsAnti-Müllerian hormone levelsOral contraceptive pill useLower AMH levelsDecreased ovarian reserveBody mass indexContraceptive pill useBRCA pathogenic variantsEvaluable womenMass indexMean ageHormone levelsBreast cancerAffected womenPill useMeta-AnalysisYoung women
2020
Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
Goldfarb S, Turan V, Bedoschi G, Taylan E, Abdo N, Cigler T, Bang H, Patil S, Dickler M, Oktay K. Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer. Breast Cancer Research And Treatment 2020, 185: 165-173. PMID: 32930927, PMCID: PMC7877450, DOI: 10.1007/s10549-020-05933-7.Peer-Reviewed Original ResearchConceptsAnti-Mullerian hormoneOvarian reserveAdjuvant chemotherapyBreast cancerAMH levelsChemotherapy regimensCompletion of ACSerum AMH levelsAdjuvant tamoxifenAMH recoveryChemotherapy groupPrimary diagnosisBaseline ageMethodsOne hundredAMH assessmentRegimensChemotherapyYoung womenTamoxifenSignificant recoveryCancerMixed effects modelsMonthsTreatment effectsWomen
2013
Fertility preservation in young breast cancer patients: addressing individual patient needs
Rodriguez-Wallberg K, Oktay K. Fertility preservation in young breast cancer patients: addressing individual patient needs. Breast Cancer Management 2013, 2: 135-147. DOI: 10.2217/bmt.12.68.Peer-Reviewed Original ResearchBreast cancer patientsFertility preservationCancer patientsAromatase inhibitorsYoung breast cancer patientsOvarian cortical tissueNumber of oocytesStandard stimulation protocolIndividual patient needsReports of childrenFemale patientsEstradiol levelsMenstrual cycleOocyte freezingBreast cancerPsychosocial distressStimulation protocolNormal rangePatient needsPatientsCortical tissueYoung womenImmature oocytesTamoxifenInfertility
2008
Fertility Issues and Options in Young Women with Cancer
Oktay K, Sönmezer M. Fertility Issues and Options in Young Women with Cancer. Recent Results In Cancer Research 2008, 178: 203-224. PMID: 18080455, DOI: 10.1007/978-3-540-71274-9_18.Peer-Reviewed Original ResearchConceptsFemale cancersHematopoietic stem cell transplantationLong-term complicationsStem cell transplantationCurrent treatment modalitiesNew cancer casesMultiagent chemotherapyCell transplantationCure rateTreatment modalitiesCancer incidenceSurgical techniqueCancer casesCertain malignanciesRadiation therapyFertility issuesCancerYoung womenDeath rate
2006
P-165 The first live birth after the use of aromatase inhibitors for induction of ovulation in young women with endometrial carcinoma
Azim A, Lostritto K, Oktay K. P-165 The first live birth after the use of aromatase inhibitors for induction of ovulation in young women with endometrial carcinoma. Fertility And Sterility 2006, 86: s193-s194. DOI: 10.1016/j.fertnstert.2006.07.513.Peer-Reviewed Original Research
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomen