2024
Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers
Erden M, Gayete-Lafuente S, Vural N, Oktay K. Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers. Obstetrics And Gynecology 2024, 144: 481-492. PMID: 39173181, PMCID: PMC11499045, DOI: 10.1097/aog.0000000000005708.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue cryopreservationOvarian tissue transplantationTissue cryopreservationAutologous transplantationGynecologic cancerTissue transplantationOutcome of autologous transplantationPreserving ovarian functionCochrane Library databasesOvarian endocrine functionPooled-effect estimatesSystematic reviewRisk-of-bias assessmentOvarian stimulationHematologic malignanciesLonger-term outcomesFertility preservationOvarian functionBreast cancerLibrary databasesTransplantationGraft longevityCancerEndocrine functionModeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2022
Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause
Oktay K, Marin L. Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause. 2022, 193-201. DOI: 10.1016/b978-0-12-823344-3.00003-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationHealthy womenTissue cryopreservationOvarian tissue harvestingOvarian tissue freezingRisk-benefit assessmentOvarian cryopreservationClinical guidelinesReproductive yearsAmount of tissueMedical indicationsReproductive agingTransplantation techniquesTissue harvestingMenopauseTransplantationWomenTissue freezingCryopreservationChapter 17 Approach to Follow Up After Ovarian Transplantation
Pacheco F, Oktay K. Chapter 17 Approach to Follow Up After Ovarian Transplantation. 2022, 177-184. DOI: 10.1016/b978-0-12-823344-3.00015-7.Peer-Reviewed Original ResearchGraft functionOvarian transplantationAcute postoperative phaseImmediate postoperative complicationsMedical specialistsLong-term careWay pregnancyPostoperative complicationsPostoperative periodTransplantation recipientsIVF attemptsPharmacological supportPostoperative phasePregnancy attemptsOvarian functionPreoperative preparationSimple surgeryNumerous medical problemsClose monitoringPatient's diseaseRecurrence riskMedical problemsTransplantationDiseaseMethod of choiceChapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation
Marin L, Oktay K. Chapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation. 2022, 1-9. DOI: 10.1016/b978-0-12-823344-3.00017-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFertility preservation approachSubsequent animal studiesOvarian autotransplantationRadical surgeryGonadotoxic treatmentClinical progressAnimal studiesPreclinical developmentReproductive medicineAutotransplantationAmerican SocietyTransplantationSuccessful experimental studiesCurrent successPreservation approachSubsequent progressPatientsSurgeryCryopreservation
2021
AUTOLOGOUS CRYOPRESERVED OVARIAN TISSUE TRANSPLANTATION (ACOTT): AN UPDATE FROM OUR PREVIOUS META-ANALYTICAL DATASET AS OF MARCH 2021
Pacheco F, Marin L, Oktay K. AUTOLOGOUS CRYOPRESERVED OVARIAN TISSUE TRANSPLANTATION (ACOTT): AN UPDATE FROM OUR PREVIOUS META-ANALYTICAL DATASET AS OF MARCH 2021. Fertility And Sterility 2021, 116: e217. DOI: 10.1016/j.fertnstert.2021.07.590.Peer-Reviewed Original ResearchPreservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation
Oktay K. Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation. The Biomedical & Life Sciences Collection 2021, 2021: e1005610. DOI: 10.69645/qtwq1550.Peer-Reviewed Original ResearchDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantation
2019
Advances in fertility-preservation surgery: navigating new frontiers
Christianson M, Oktay K. Advances in fertility-preservation surgery: navigating new frontiers. Fertility And Sterility 2019, 112: 438-445. PMID: 31446903, DOI: 10.1016/j.fertnstert.2019.06.029.Peer-Reviewed Original ResearchConceptsFertility preservation surgeryFertility preservationSurgical optionsVital reproductive organFertility-preserving surgeryUterine fixationRadical trachelectomyGynecologic malignanciesFemale patientsFirst transplantationCancer patientsReproductive organsFuture fertilityReproductive surgeryMedical conditionsTransposition procedureSelect cancersSurgerySurgical creativityTissue 20PatientsMajor advancesOrgansTrachelectomyTransplantationChapter 30 Autologous Transplantation of Human Ovarian Tissue
Taylan E, Oktay K. Chapter 30 Autologous Transplantation of Human Ovarian Tissue. 2019, 493-500. DOI: 10.1016/b978-0-12-813209-8.00030-3.Peer-Reviewed Original ResearchHuman ovarian tissueOvarian tissueAutologous transplantationFrozen-thawed human ovarian tissueOvarian tissue cryopreservationReproductive-age womenPremature ovarian failureOvarian reserveGonadotoxic therapyAntineoplastic treatmentGonadotoxic treatmentFertility preservationOvarian cortexOvarian failureAge womenReproductive surgeryTissue cryopreservationEndocrine functionPrimordial folliclesPrepubertal ageNononcological diseasesTransplantationTreatmentDiseaseTissue
2016
Current succes and efficiency of autologous ovarian transplantation with cryopreserved tissue: a meta-analysis
Oktay K, Pacheco F. Current succes and efficiency of autologous ovarian transplantation with cryopreserved tissue: a meta-analysis. Fertility And Sterility 2016, 106: e131-e132. DOI: 10.1016/j.fertnstert.2016.07.392.Peer-Reviewed Original Research
2015
Ovarian Tissue Cryopreservation: Where Are We Now?
Bedoschi G, Oktay K. Ovarian Tissue Cryopreservation: Where Are We Now? 2015, 71-78. DOI: 10.1007/978-3-319-17849-3_6.Peer-Reviewed Original ResearchFertility preservationOvarian stimulationOvarian cortical piecesAdvanced treatment strategiesPre-pubertal childrenOvarian cryopreservationCortical piecesSurvival outcomesOvarian functionCancer careCancer patientsTreatment strategiesEndocrine functionOocyte cryopreservationAccelerated phaseEarly detectionCancer communityPatientsTransplantationFirst descriptionStimulationSufficient time periodChemotherapySuccessful restorationCancer
2014
Robotically assisted ovarian tissue transplantation with human extracellular matrix: ovarian stimulation and in vitro fertilization outcomes
Oktay K, Bedoschi G, Pacheco F, Stobezki R, Turan V. Robotically assisted ovarian tissue transplantation with human extracellular matrix: ovarian stimulation and in vitro fertilization outcomes. Fertility And Sterility 2014, 102: e37. DOI: 10.1016/j.fertnstert.2014.07.132.Peer-Reviewed Original Research
2010
Improving autologous ovarian transplantation with frozen-banked tissue: robotic assistance and the utilization of a human regenerative matrix
Oktay K, Soleimani R, Lee S, Ozkavukcu S, Brito M, Babayev S. Improving autologous ovarian transplantation with frozen-banked tissue: robotic assistance and the utilization of a human regenerative matrix. Fertility And Sterility 2010, 94: s89. DOI: 10.1016/j.fertnstert.2010.07.344.Peer-Reviewed Original ResearchPreserving Fertility
Oktay K, Oktem O. Preserving Fertility. 2010, 703-710. DOI: 10.1007/978-1-4419-1436-1_47.Peer-Reviewed Original ResearchTreatment-related adverse outcomesAdolescent female patientsFemale reproductive functionPrimary illnessFemale patientsOvarian cryopreservationFertility preservationAdverse outcomesReproductive functionCancer treatment methodsHuman reproductionTreatment methodsCurrent strategiesPatientsTransplantationTherapyIllnessCancer
2009
Recurrent spontaneous pregnancies and live births following heterotopic transplantation of frozen banked ovarian tissue despite the absence of follicular activity in the remaining menopausal ovary
Oktay K. Recurrent spontaneous pregnancies and live births following heterotopic transplantation of frozen banked ovarian tissue despite the absence of follicular activity in the remaining menopausal ovary. Fertility And Sterility 2009, 92: s66. DOI: 10.1016/j.fertnstert.2009.07.255.Peer-Reviewed Original Research
2005
Sustained Endocrine Function And Spontaneous Pregnancies After Subcutaneous Transplantation Of Cryopreserved Ovarian Tissue In Stem Cell Transplant Recipients
Oktay K, Oktem O. Sustained Endocrine Function And Spontaneous Pregnancies After Subcutaneous Transplantation Of Cryopreserved Ovarian Tissue In Stem Cell Transplant Recipients. Fertility And Sterility 2005, 84: s68. DOI: 10.1016/j.fertnstert.2005.07.162.Peer-Reviewed Original Research
2002
The potential of ovarian tissue transplant to preserve fertility
Buyuk E, Oktay K. The potential of ovarian tissue transplant to preserve fertility. Expert Opinion On Biological Therapy 2002, 2: 361-370. PMID: 11955275, DOI: 10.1517/14712598.2.4.361.Peer-Reviewed Original ResearchConceptsClinical studiesOvarian tissue transplantsSafety of pregnancyFuture clinical trialsPremature ovarian failureOvarian follicle developmentOvarian graftsOvarian cryopreservationOvarian transplantationOvarian functionCancer patientsOvarian failureClinical trialsAnimal studiesTissue transplantsOvarian tissueFurther basic researchHormone productionFollicle developmentRevascularisation processPregnancyPatientsTransplantationWomenSafetyPreliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips
Oktay K, Yih M. Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips. Seminars In Reproductive Medicine 2002, 20: 063-074. PMID: 11941536, DOI: 10.1055/s-2002-23520.Peer-Reviewed Original ResearchConceptsOvarian cortical stripsOvarian transplantationOvarian tissueCortical stripsHeterotopic transplantationAutologous ovarian transplantationFrozen ovarian tissueHeterotopic techniqueNew York surgeonPatient selectionOvarian functionSurgical techniqueTransplantationTransplanted tissuePreliminary experienceExperimental modelOperating roomCancer cellsClinical applicationTissueSafety measuresOrthotopicCliniciansSurgeonsTrounson
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomen