2024
Trends and regional differences for fertility preservation procedures in women with breast cancer
Turan V, Bedoschi G, Lee D, Barbosa C, de Oliveira R, Sacinti K, Sonmezer M, Lambertini M, Massarotti C, Schaub A, Wang E, Gayete-Lafuente S, Dunlop C, Anderson R, Bang H, Oktay K. Trends and regional differences for fertility preservation procedures in women with breast cancer. Clinical Breast Cancer 2024 PMID: 39428290, DOI: 10.1016/j.clbc.2024.09.011.Peer-Reviewed Original ResearchWomen of reproductive ageFertility preservationBreast cancerTissue cryopreservationYoung womenReproductive ageOvarian tissue cryopreservationFertility preservation methodsNormal ovarian functionOvarian stimulation cyclesFertility preservation proceduresFertility preservation practicesDiagnosed breast cancerOocyte cryopreservationOvarian stimulationTertiary centerMulticenter studyOvarian functionStimulated cyclesParticipating centersRegional time trendsBreastCancerPreservation proceduresChemotherapyUtility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers
Erden M, Gayete-Lafuente S, Vural N, Oktay K. Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers. Obstetrics And Gynecology 2024, 144: 481-492. PMID: 39173181, PMCID: PMC11499045, DOI: 10.1097/aog.0000000000005708.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue cryopreservationOvarian tissue transplantationTissue cryopreservationAutologous transplantationGynecologic cancerTissue transplantationOutcome of autologous transplantationPreserving ovarian functionCochrane Library databasesOvarian endocrine functionPooled-effect estimatesSystematic reviewRisk-of-bias assessmentOvarian stimulationHematologic malignanciesLonger-term outcomesFertility preservationOvarian functionBreast cancerLibrary databasesTransplantationGraft longevityCancerEndocrine functionPerinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis
Erden M, Uyanik E, Demeestere I, Oktay K. Perinatal outcomes of pregnancies following autologous cryopreserved ovarian tissue transplantation: a systematic review with pooled analysis. American Journal Of Obstetrics And Gynecology 2024, 231: 480-489. PMID: 38621483, PMCID: PMC11473709, DOI: 10.1016/j.ajog.2024.04.012.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue transplantationPerinatal complication rateOvarian tissue cryopreservationPerinatal outcomesGestational ageAssisted reproductive techniquesPre-eclampsiaTissue transplantationTissue cryopreservationComplication rateIncidence of gestational diabetesLarge-for-gestational-agePreterm premature rupture of membranesIncidence of gestational diabetes mellitusPerinatal outcomes of pregnanciesPremature rupture of membranesHypertensive disorders of pregnancyReproductive techniquesPre-eclampsia incidenceObservational studyPreterm premature ruptureRupture of membranesComprehensive search of MEDLINEDisorders of pregnancy895 The utility, safety and outcomes of ovarian tissue cryopreservation for gynecologic cancers: an analysis from a large fertility preservation program and systematic review of the literature
Erden M, Gayete-Lafuente S, Vural N, Oktay K. 895 The utility, safety and outcomes of ovarian tissue cryopreservation for gynecologic cancers: an analysis from a large fertility preservation program and systematic review of the literature. 2024, a243.2-a244. DOI: 10.1136/ijgc-2024-esgo.473.Peer-Reviewed Original ResearchTo the editor: patient selection for ovarian tissue cryopreservation: should there be a strict age limit?
Marin L, Pacheco F, Oktay K. To the editor: patient selection for ovarian tissue cryopreservation: should there be a strict age limit? Fertility And Sterility 2024, 121: 894-895. PMID: 38346551, DOI: 10.1016/j.fertnstert.2024.02.007.Peer-Reviewed Original ResearchModeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvestFemale Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
2022
Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderChapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause
Oktay K, Marin L. Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause. 2022, 193-201. DOI: 10.1016/b978-0-12-823344-3.00003-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationHealthy womenTissue cryopreservationOvarian tissue harvestingOvarian tissue freezingRisk-benefit assessmentOvarian cryopreservationClinical guidelinesReproductive yearsAmount of tissueMedical indicationsReproductive agingTransplantation techniquesTissue harvestingMenopauseTransplantationWomenTissue freezingCryopreservationChapter 11 Preoperative Evaluation and Preparation for Ovarian Tissue Transplant Surgery
Oktay K, Turan V. Chapter 11 Preoperative Evaluation and Preparation for Ovarian Tissue Transplant Surgery. 2022, 109-115. DOI: 10.1016/b978-0-12-823344-3.00009-1.Peer-Reviewed Original ResearchPreoperative evaluationTransplantation surgeryFertility preservation methodsOvarian tissue cryopreservationOvarian autotransplantationOvarian stimulationHealthy babyTransplant surgeryPrepubertal girlsTissue cryopreservationSurgeryWomenPreparation of womenOnly optionAutotransplantationChemotherapyBabiesEvaluationChapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation
Marin L, Oktay K. Chapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation. 2022, 1-9. DOI: 10.1016/b978-0-12-823344-3.00017-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFertility preservation approachSubsequent animal studiesOvarian autotransplantationRadical surgeryGonadotoxic treatmentClinical progressAnimal studiesPreclinical developmentReproductive medicineAutotransplantationAmerican SocietyTransplantationSuccessful experimental studiesCurrent successPreservation approachSubsequent progressPatientsSurgeryCryopreservationChapter 15 Surgical Approach to Laparoscopic and Robot-Assisted Ovarian Tissue Transplantation
Oktay K, Bedoschi G. Chapter 15 Surgical Approach to Laparoscopic and Robot-Assisted Ovarian Tissue Transplantation. 2022, 157-167. DOI: 10.1016/b978-0-12-823344-3.00023-6.Peer-Reviewed Original Research
2021
FERTILITY PRESERVATION MANAGEMENT AND OVARIAN TISSUE CRYOPRESERVATION IN AN INFANT GIRL WITH CLASSIC GALACTOSEMIA
Szymanska K, Vash-Margita A, Gunther K, Rodriguez-Buritica D, Oktay K. FERTILITY PRESERVATION MANAGEMENT AND OVARIAN TISSUE CRYOPRESERVATION IN AN INFANT GIRL WITH CLASSIC GALACTOSEMIA. Fertility And Sterility 2021, 116: e57. DOI: 10.1016/j.fertnstert.2021.07.162.Peer-Reviewed Original ResearchPreservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation
Oktay K. Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation. The Biomedical & Life Sciences Collection 2021, 2021: e1005610. DOI: 10.69645/qtwq1550.Peer-Reviewed Original ResearchComparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezingDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantation
2019
Chapter 30 Autologous Transplantation of Human Ovarian Tissue
Taylan E, Oktay K. Chapter 30 Autologous Transplantation of Human Ovarian Tissue. 2019, 493-500. DOI: 10.1016/b978-0-12-813209-8.00030-3.Peer-Reviewed Original ResearchHuman ovarian tissueOvarian tissueAutologous transplantationFrozen-thawed human ovarian tissueOvarian tissue cryopreservationReproductive-age womenPremature ovarian failureOvarian reserveGonadotoxic therapyAntineoplastic treatmentGonadotoxic treatmentFertility preservationOvarian cortexOvarian failureAge womenReproductive surgeryTissue cryopreservationEndocrine functionPrimordial folliclesPrepubertal ageNononcological diseasesTransplantationTreatmentDiseaseTissue
2018
Ovarian tissue cryopreservation and transplantation
Bedoschi G, Oktay K. Ovarian tissue cryopreservation and transplantation. 2018, 148-152. DOI: 10.1201/9781351141680-19.Peer-Reviewed Original ResearchOvarian tissue cryopreservationOvarian cortical piecesFertility preservationAdvanced treatment strategiesOvarian transplantationCortical piecesOvarian stimulationSurvival outcomesOvarian functionTreatment strategiesTissue cryopreservationAccelerated phaseEarly detectionHeterotopic ovarian transplantationFertility preservation proceduresLower abdominal wallFirst descriptionOvarian endocrineInitial ischemiaOvarian cryopreservationPharmacological supportTransplant proceduresFollicle lossCancer careCancer patients
2012
Evaluation of ovarian and testicular tissue cryopreservation and their bundling with medically-indicated procedures in children undergoing gonadotoxic therapies for blood dyscrasias or cancer
Babayev S, Karsy M, Arslan E, Kogan S, Oktay K. Evaluation of ovarian and testicular tissue cryopreservation and their bundling with medically-indicated procedures in children undergoing gonadotoxic therapies for blood dyscrasias or cancer. Fertility And Sterility 2012, 98: s36. DOI: 10.1016/j.fertnstert.2012.07.132.Peer-Reviewed Original ResearchTesticular tissue cryopreservationGonadotoxic therapyBlood dyscrasiasTissue cryopreservationDyscrasiasTherapyCancer
2005
Oocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications
Shamonki M, Oktay K. Oocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications. Seminars In Reproductive Medicine 2005, 23: 266-276. PMID: 16059833, DOI: 10.1055/s-2005-872455.Peer-Reviewed Original Research