2024
Female Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
2022
Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorder
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2019
Chapter 30 Autologous Transplantation of Human Ovarian Tissue
Taylan E, Oktay K. Chapter 30 Autologous Transplantation of Human Ovarian Tissue. 2019, 493-500. DOI: 10.1016/b978-0-12-813209-8.00030-3.Peer-Reviewed Original ResearchHuman ovarian tissueOvarian tissueAutologous transplantationFrozen-thawed human ovarian tissueOvarian tissue cryopreservationReproductive-age womenPremature ovarian failureOvarian reserveGonadotoxic therapyAntineoplastic treatmentGonadotoxic treatmentFertility preservationOvarian cortexOvarian failureAge womenReproductive surgeryTissue cryopreservationEndocrine functionPrimordial folliclesPrepubertal ageNononcological diseasesTransplantationTreatmentDiseaseTissue
2012
Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease
2000
Ovarian cryopreservation and transplantation: basic aspects
Oktay K, Karlikaya G, Aydin B. Ovarian cryopreservation and transplantation: basic aspects. Molecular And Cellular Endocrinology 2000, 169: 105-108. PMID: 11155939, DOI: 10.1016/s0303-7207(00)00361-0.Peer-Reviewed Original ResearchTransplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice
Oktay K, Newton H, Gosden R. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertility And Sterility 2000, 73: 599-603. PMID: 10689020, DOI: 10.1016/s0015-0282(99)00548-8.Peer-Reviewed Original ResearchConceptsOvarian tissueSCID miceFrozen-thawed human ovarian tissueFrozen-thawed ovarian tissueAutologous ovarian transplantationFrozen-thawed graftsHuman ovarian tissueFollicle growth initiationLong-term survivalWeeks of graftingHuman primordial folliclesFollicle countOvarian transplantationImmunodeficiency miceMAIN OUTCOMEHealthy folliclesPrimordial folliclesAcademic centersAnimal studiesFollicle stageAdvanced folliclesFolliclesGraftMiceNecrotic cellsNew Strategies in Studying Ovarian Aging
Oktay K, Karlikaya G, Bayrakceken A. New Strategies in Studying Ovarian Aging. Serono Symposia USA 2000, 80-88. DOI: 10.1007/978-0-387-21628-7_8.Peer-Reviewed Original Research
1998
Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology?
Oktay K, Newton H, Aubard Y, Salha O, G.Gosden R. Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology? Fertility And Sterility 1998, 69: 1-7. PMID: 9457923, DOI: 10.1016/s0015-0282(97)00207-0.Peer-Reviewed Original ResearchConceptsOvarian tissueConservation of fertilityHigh-dose chemotherapyOvarian tissue cryopreservationImmature human oocytesOvarian biopsy samplesOvarian tissue bankingNeeds of patientsLong-term survivorshipCryopreservation of oocytesHealthy womenOvarian stromaImmature folliclesTissue cryopreservationPrimordial folliclesBiopsy samplesFollicle growthNeedy patientsImmature oocytesPatientsHuman oocytesDisappointing resultsOocyte fertilityReproductive optionsFollicles
1997
Ontogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles1
Oktay K, Briggs D, Gosden R. Ontogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles1. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 3748-3751. PMID: 9360535, DOI: 10.1210/jcem.82.11.4346.Peer-Reviewed Original ResearchConceptsMessenger ribonucleic acidPrimordial folliclesFollicle stageElective cesarean sectionHuman ovarian folliclesPreantral follicle developmentFSH receptor geneHormone receptor gene expressionReceptor gene expressionFollicle-stimulating hormone receptor gene expressionCesarean sectionRectus muscleHuman ovaryAntral folliclesFollicular growthFSH expressionHuman folliculogenesisOvarian folliclesOvarian tissueGranulosa cellsMultilaminar folliclesStromal tissueSingle follicleFollicle developmentFolliclesIsolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue
Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden R. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertility And Sterility 1997, 67: 481-486. PMID: 9091334, DOI: 10.1016/s0015-0282(97)80073-8.Peer-Reviewed Original ResearchConceptsHuman ovarian tissuePrimordial folliclesOvarian tissueWhole folliclesElective cesarean sectionLeeds General InfirmaryCryopreserved ovarian tissueHuman primordial folliclesCesarean sectionHealthy womenOvarian biopsyFollicle countingGeneral InfirmaryMAIN OUTCOMEFollicle viabilityUltrastructural signsFrozen-thawed groupFolliclesFresh groupTissuePropidium iodideSuccinimidyl esterViability ratePercent viabilityOocytes
1996
Follicle freezing and autografting. A new method of medically assisted procreation?.
Aubard Y, Newton H, Oktay K, Piver P, Gosden R. Follicle freezing and autografting. A new method of medically assisted procreation?. La Presse Médicale 1996, 25: 921-3. PMID: 8685154.Peer-Reviewed Original ResearchConceptsOvulatory capacityHuman folliclePrimordial folliclesQuantity of folliclesUse of allograftsLarge animal modelImmunosuppressive therapyDestructive therapySuccessful treatmentOvarian fragmentsSurvival timeAnimal modelsOvarian tissueFollicular tissueFolliclesExperimental modelTherapyAge limitTissueHuman tissuesOvocytesEncouraging resultsOptimal siteReimplantationAllografts
1995
Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1
Oktay K, Schenken R, Nelson J. Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1. Biology Of Reproduction 1995, 53: 295-301. PMID: 7492681, DOI: 10.1095/biolreprod53.2.295.Peer-Reviewed Original ResearchConceptsPCNA expressionPrimary folliclesFollicle growthCell nuclear antigenAntral folliclesFollicular growthPCNA immunoreactivityGranulosa cellsNuclear antigenEarly primary folliclesGranulosa cell layerTransitional folliclesControl ratsAdult ratsPrimordial folliclesSensitive markerPCNA stainingAtretic folliclesRat ovaryOocyte enlargementProliferating Cell Nuclear AntigenEarly signsFolliclesParaffin sectionsPregranulosa cells