2009
Association of BRCA1 mutations with diminished ovarian reserve: A common genetic mechanism for breast/ovarian cancer, and infertility?
Oktay K, Kim J, Barad D, Gleicher N, Babayev S. Association of BRCA1 mutations with diminished ovarian reserve: A common genetic mechanism for breast/ovarian cancer, and infertility? Journal Of Clinical Oncology 2009, 27: 11039-11039. DOI: 10.1200/jco.2009.27.15_suppl.11039.Peer-Reviewed Original ResearchRelative riskOvarian reserveBRCA mutationsBreast cancerFertility preservationHereditary breast-ovarian cancer syndromeOocyte reserveBRCA1 mutationsBreast-ovarian cancer syndromeOvarian stimulation protocolsDiminished ovarian reservePreservation of fertilityPossible higher riskOvarian cancer syndromeNumber of oocytesBreast/ovarian cancerPoor response ratesInfertility historyPoor respondersBC patientsMean ageNon-invasive methodOvarian failureOvarian cancerBRCA2 mutations
1996
Diminished α-inhibin messenger ribonucleic acid in in vitro fertilization-embryo transfer poor responders reflects declining follicle reserve**Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994.
Burns W, Oktay K, Tekmal R, Nelson J, Schenken R. Diminished α-inhibin messenger ribonucleic acid in in vitro fertilization-embryo transfer poor responders reflects declining follicle reserve**Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. Fertility And Sterility 1996, 65: 394-399. PMID: 8566269, DOI: 10.1016/s0015-0282(16)58106-0.Peer-Reviewed Original ResearchConceptsPoor respondersGood respondersMessenger RNA levelsOvarian responsivenessIVF-ETMRNA levelsPg/Academic tertiary care institutionGranulosa cell samplesRNA levelsDay of hCGTertiary care institutionGranulosa cell functionTotal mRNAGynecologic InvestigationFollicle numberFollicle aspirationE2 concentrationsMessenger ribonucleic acidRespondersFolliclesCare institutionsCell functionDecreased poolRecent reports