2024
Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study
Loggers E, Chugh R, Federman N, Hartner L, Riedel R, Cho S, Hyslop D, Lim A, Oton A, Oktay K. Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study. Cancer 2024, 130: 2812-2821. PMID: 38703010, DOI: 10.1002/cncr.35324.Peer-Reviewed Original ResearchFemales of reproductive potentialFollicle-stimulating hormoneReturn of menstruationOvarian toxicityDesmoid tumorsFollow-upContinuous 28-day cyclesLost to follow-upPhase 3 studyProgressive desmoid tumorsPost hoc analysisSafety populationNirogacestatStopping treatmentHormone valuesSafety signalsHoc analysisPatientsPerimenopausal symptomsMenstruationGamma-secretase inhibitorsPlaceboRandom femalesTumorEvent follow-up
2022
IS IT SAFE TO PERFORM OVARIAN CRYOPRESERVATION AND TRANSPLANTATION IN PATIENTS WITH LEUKEMIA A 5-YEAR SURVIVAL ANALYSIS DATA
Sonmezer M, Sükür Y, Saçinti K, Ozkavukcu S, Kankaya D, Seval G, Atabekoglu C, Oktay K. IS IT SAFE TO PERFORM OVARIAN CRYOPRESERVATION AND TRANSPLANTATION IN PATIENTS WITH LEUKEMIA A 5-YEAR SURVIVAL ANALYSIS DATA. Fertility And Sterility 2022, 118: e202. DOI: 10.1016/j.fertnstert.2022.08.575.Peer-Reviewed Original ResearchChapter 18 Approach to Ovarian Stimulation and In Vitro Fertilization in Patients With Transplanted Ovarian Tissue
Oktay K, Babayev S. Chapter 18 Approach to Ovarian Stimulation and In Vitro Fertilization in Patients With Transplanted Ovarian Tissue. 2022, 185-192. DOI: 10.1016/b978-0-12-823344-3.00010-8.Peer-Reviewed Original ResearchOvarian stimulationOvarian autotransplantsIVF outcomesOvarian tissueOptimal ovarian stimulationOvarian stimulation cyclesStandard ovarian stimulationTransplanted ovarian tissueFollicular growth patternOvarian transplantsExtrapelvic locationsStimulation cyclesVitro FertilizationSame womenStimulationWomenAutotransplantsSignificant differencesFertilization protocolsOutcomesTissueGrowth patternPatientsTransplantAvailable dataChapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation
Marin L, Oktay K. Chapter 1 Scientific History of Ovarian Tissue Cryopreservation and Transplantation. 2022, 1-9. DOI: 10.1016/b978-0-12-823344-3.00017-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFertility preservation approachSubsequent animal studiesOvarian autotransplantationRadical surgeryGonadotoxic treatmentClinical progressAnimal studiesPreclinical developmentReproductive medicineAutotransplantationAmerican SocietyTransplantationSuccessful experimental studiesCurrent successPreservation approachSubsequent progressPatientsSurgeryCryopreservation
2021
Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation
Oktay K. Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation. The Biomedical & Life Sciences Collection 2021, 2021: e1005610. DOI: 10.69645/qtwq1550.Peer-Reviewed Original Research
2019
Ovarian Stimulation in Women with Breast Cancer
Turan V, Oktay K. Ovarian Stimulation in Women with Breast Cancer. 2019, 105-115. DOI: 10.1007/978-3-030-24086-8_10.Peer-Reviewed Original ResearchFertility preservation optionsOvarian stimulationBreast cancerPreservation optionsEffective fertility preservation optionsEstrogen-sensitive malignanciesReproductive-aged womenCommon cancer typesCytotoxic chemotherapyGonadal failureAged womenOocyte cryopreservationNumber of womenCancer typesCancerWomenStimulationTreatmentHigh levelsChemotherapyPatientsMalignancyOptionsRadiotherapyEstradiolAdvances in fertility-preservation surgery: navigating new frontiers
Christianson M, Oktay K. Advances in fertility-preservation surgery: navigating new frontiers. Fertility And Sterility 2019, 112: 438-445. PMID: 31446903, DOI: 10.1016/j.fertnstert.2019.06.029.Peer-Reviewed Original ResearchConceptsFertility preservation surgeryFertility preservationSurgical optionsVital reproductive organFertility-preserving surgeryUterine fixationRadical trachelectomyGynecologic malignanciesFemale patientsFirst transplantationCancer patientsReproductive organsFuture fertilityReproductive surgeryMedical conditionsTransposition procedureSelect cancersSurgerySurgical creativityTissue 20PatientsMajor advancesOrgansTrachelectomyTransplantation
2016
Embryo Cryopreservation in Breast Cancer Patients
Bedoschi G, Oktay K. Embryo Cryopreservation in Breast Cancer Patients. 2016, 39-52. DOI: 10.1007/978-4-431-55963-4_3.Peer-Reviewed Original ResearchBreast cancer patientsCancer patientsFertility preservationEmbryo cryopreservationAdjuvant systemic chemotherapyFertility preservation techniquesOvarian stimulation protocolsBreast cancer casesOvarian stimulationSystemic chemotherapyOvarian reserveIncident casesAromatase inhibitorsBreast cancerCancer casesStimulation protocolPatientsDonor semenCommon typeWomenFuture reproductive potentialCancerPreservation techniquesAttractive strategySpecial considerationCurrent State of Fertility Preservation in Cancer Patients—What is Established and What is Still Controversial?
Oktay K, Bedoschi G. Current State of Fertility Preservation in Cancer Patients—What is Established and What is Still Controversial? TouchREVIEWS In Oncology & Haematology 2016, 12: 33. DOI: 10.17925/ohr.2016.12.01.33.Peer-Reviewed Original Research
2015
Ovarian Tissue Cryopreservation: Where Are We Now?
Bedoschi G, Oktay K. Ovarian Tissue Cryopreservation: Where Are We Now? 2015, 71-78. DOI: 10.1007/978-3-319-17849-3_6.Peer-Reviewed Original ResearchFertility preservationOvarian stimulationOvarian cortical piecesAdvanced treatment strategiesPre-pubertal childrenOvarian cryopreservationCortical piecesSurvival outcomesOvarian functionCancer careCancer patientsTreatment strategiesEndocrine functionOocyte cryopreservationAccelerated phaseEarly detectionCancer communityPatientsTransplantationFirst descriptionStimulationSufficient time periodChemotherapySuccessful restorationCancer
2014
Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropin in patients with breast cancer: a prospective controlled study with subgroup analysis
Kim J, Turan V, Oktay K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropin in patients with breast cancer: a prospective controlled study with subgroup analysis. Fertility And Sterility 2014, 102: e32. DOI: 10.1016/j.fertnstert.2014.07.118.Peer-Reviewed Original Research
2013
Simplified cycle management for breast cancer patients undergoing fertility preservation with the Letrozole-FSH stimulation protocol
Bedoschi G, Turan V, Moy F, Oktay K. Simplified cycle management for breast cancer patients undergoing fertility preservation with the Letrozole-FSH stimulation protocol. Fertility And Sterility 2013, 100: s169. DOI: 10.1016/j.fertnstert.2013.07.1468.Peer-Reviewed Original ResearchFrozen embryo transfer pregnancy outcomes in breast cancer patients who were stimulated with Letrozole-FSH for fertility preservation
Bedoschi G, Turan V, Oktay K. Frozen embryo transfer pregnancy outcomes in breast cancer patients who were stimulated with Letrozole-FSH for fertility preservation. Fertility And Sterility 2013, 100: s166. DOI: 10.1016/j.fertnstert.2013.07.1455.Peer-Reviewed Original ResearchFertility preservation in young breast cancer patients: addressing individual patient needs
Rodriguez-Wallberg K, Oktay K. Fertility preservation in young breast cancer patients: addressing individual patient needs. Breast Cancer Management 2013, 2: 135-147. DOI: 10.2217/bmt.12.68.Peer-Reviewed Original ResearchBreast cancer patientsFertility preservationCancer patientsAromatase inhibitorsYoung breast cancer patientsOvarian cortical tissueNumber of oocytesStandard stimulation protocolIndividual patient needsReports of childrenFemale patientsEstradiol levelsMenstrual cycleOocyte freezingBreast cancerPsychosocial distressStimulation protocolNormal rangePatient needsPatientsCortical tissueYoung womenImmature oocytesTamoxifenInfertilityFertility preservation in the female with cancer
Rodriguez-Wallberg K, Oktay K. Fertility preservation in the female with cancer. 2013, 273-281. DOI: 10.1017/cbo9780511997761.031.Peer-Reviewed Original ResearchFertility preservationMale cancer patientsFertility preservation strategiesImpact of cancerPost-treatment managementHormone therapySuch patientsCancer patientsNursing staffArtificial reproductive technologiesReproductive endocrinologyTesticular tissueReproductive medicineCancerReproductive technologiesPatientsMale fertilityCliniciansMenCryopreservation of spermChemotherapyPreservation strategiesSurgeryOncologistsTherapy
2012
The Patient with a History of Estrogen‐Receptor Positive Cancer
Sönmezer M, Oktay K. The Patient with a History of Estrogen‐Receptor Positive Cancer. 2012, 205-207. DOI: 10.1002/9781444398854.ch49.Peer-Reviewed Original ResearchOvarian cryopreservation.
Jeong K, Aslan E, Ozkaya E, Sonmezer M, Oktay K. Ovarian cryopreservation. Minerva Medica 2012, 103: 37-46. PMID: 22278067.Peer-Reviewed Original ResearchConceptsFertility preservationOvarian tissueNon-malignant diseasesFuture autotransplantationOvarian cryopreservationOvarian failurePrepubertal girlsReproductive endocrinologistsMalignant cellsTeam approachWhole ovariesHeterotopic locationNew promising strategyAutotransplantationSignificant delayDiseaseTissue piecesTissuePromising strategySlow freezingChemotherapyLaparoscopyPatientsEndocrinologistsOncologists
2011
OC14.06: The role of antral follicle counts (AFC) via TVUSG in determining fertility preservation outcomes in cancer patients undergoing ovarian stimulation
Arslan E, Karsy M, Moy F, Oktay K. OC14.06: The role of antral follicle counts (AFC) via TVUSG in determining fertility preservation outcomes in cancer patients undergoing ovarian stimulation. Ultrasound In Obstetrics And Gynecology 2011, 38: 27-27. DOI: 10.1002/uog.9171.Peer-Reviewed Original ResearchThe role of combined anti-mullerian hormone and antral follicle count assessment in predicting cycle outcomes in cancer patients undergoing controlled ovarian stimulation for fertility preservation
Arslan E, Karsy M, Moy F, Oktay K. The role of combined anti-mullerian hormone and antral follicle count assessment in predicting cycle outcomes in cancer patients undergoing controlled ovarian stimulation for fertility preservation. Fertility And Sterility 2011, 96: s201. DOI: 10.1016/j.fertnstert.2011.07.778.Peer-Reviewed Original ResearchSafety of pregnancy after letrozole-FSH stimulation in breast cancer patients: a prospective comparison of frozen embryo transfer to self vs. gestational carriers
Oktay K, Arslan E, Karsy M, Moy F. Safety of pregnancy after letrozole-FSH stimulation in breast cancer patients: a prospective comparison of frozen embryo transfer to self vs. gestational carriers. Fertility And Sterility 2011, 96: s42-s43. DOI: 10.1016/j.fertnstert.2011.07.162.Peer-Reviewed Original Research