2024
Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study
Loggers E, Chugh R, Federman N, Hartner L, Riedel R, Cho S, Hyslop D, Lim A, Oton A, Oktay K. Onset and resolution of ovarian toxicity with nirogacestat treatment in females with desmoid tumors: Updated safety analyses from the DeFi phase 3 study. Cancer 2024, 130: 2812-2821. PMID: 38703010, DOI: 10.1002/cncr.35324.Peer-Reviewed Original ResearchFemales of reproductive potentialFollicle-stimulating hormoneReturn of menstruationOvarian toxicityDesmoid tumorsFollow-upContinuous 28-day cyclesLost to follow-upPhase 3 studyProgressive desmoid tumorsPost hoc analysisSafety populationNirogacestatStopping treatmentHormone valuesSafety signalsHoc analysisPatientsPerimenopausal symptomsMenstruationGamma-secretase inhibitorsPlaceboRandom femalesTumorEvent follow-up
2015
Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment
Turan V, Oktay K. Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment. 2015, 47-61. DOI: 10.1016/b978-0-12-801591-9.00004-7.Peer-Reviewed Original ResearchCancer treatmentComplications of chemotherapySystemic lupus erythematosusPremature ovarian insufficiencyQuality of lifeOvarian damageLupus erythematosusOvarian toxicityAutoimmune diseasesOvarian functionBRCA mutationsReproductive ageRelative riskChemotherapy agentsClinical dataOvarian insufficiencySurvival rateChemotherapeutic agentsOvarian cellsChemotherapyHuman dataTreatmentCurrent understandingErythematosusComplications
2007
A novel xenograft model to test the ovarian toxicity of chemotherapy agents in women
Oktay K, Oktem O. A novel xenograft model to test the ovarian toxicity of chemotherapy agents in women. Journal Of Clinical Oncology 2007, 25: 19504-19504. DOI: 10.1200/jco.2007.25.18_suppl.19504.Peer-Reviewed Original ResearchXenograft modelFollicle lossClinical trialsChemotherapy agentsHuman ovarian xenograft modelPrimordial follicle countsNovel xenograft modelOvarian xenograft modelOvarian reserveFollicle countMice 12Ovarian toxicityCY injectionGonadotoxic effectsPremenopausal femalesSingle doseHuman ovaryOvarian piecesClinical studiesImmunodeficient miceSingle injectionNew agentsOvarian histologyXenograft vasculatureTUNEL staining