2024
Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2022
Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderChapter 18 Approach to Ovarian Stimulation and In Vitro Fertilization in Patients With Transplanted Ovarian Tissue
Oktay K, Babayev S. Chapter 18 Approach to Ovarian Stimulation and In Vitro Fertilization in Patients With Transplanted Ovarian Tissue. 2022, 185-192. DOI: 10.1016/b978-0-12-823344-3.00010-8.Peer-Reviewed Original ResearchOvarian stimulationOvarian autotransplantsIVF outcomesOvarian tissueOptimal ovarian stimulationOvarian stimulation cyclesStandard ovarian stimulationTransplanted ovarian tissueFollicular growth patternOvarian transplantsExtrapelvic locationsStimulation cyclesVitro FertilizationSame womenStimulationWomenAutotransplantsSignificant differencesFertilization protocolsOutcomesTissueGrowth patternPatientsTransplantAvailable data
2021
Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data
Oktay K, Marin L, Bedoschi G, Pacheco F, Sugishita Y, Kawahara T, Taylan E, Acosta C, Bang H. Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data. Fertility And Sterility 2021, 117: 181-192. PMID: 34801235, PMCID: PMC8863399, DOI: 10.1016/j.fertnstert.2021.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesCryopreservationExtracellular MatrixFemaleFertility PreservationHumansMeta-Analysis as TopicNeovascularization, PhysiologicOvaryPregnancyPregnancy RateRetrospective StudiesRobotic Surgical ProceduresTissue Culture TechniquesTissue ScaffoldsTransplantation, AutologousYoung AdultConceptsGraft longevityCase seriesOvarian functionLow-dose aspirinOvarian tissue transplantationOvarian cortical piecesLower embryo qualityOocytes/embryosNeonatal outcomesTransdermal estrogenChemotherapy exposureOvarian transplantationCortical piecesMeta-analytic dataLower abdomenHealthy childrenLive birthsMAIN OUTCOMEGraft vascularizationExtracellular matrix scaffoldsOvarian tissueAneuploidy rateFunction returnsEmbryo qualityMeta-analytic updateComparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezingDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantation
2019
Chapter 30 Autologous Transplantation of Human Ovarian Tissue
Taylan E, Oktay K. Chapter 30 Autologous Transplantation of Human Ovarian Tissue. 2019, 493-500. DOI: 10.1016/b978-0-12-813209-8.00030-3.Peer-Reviewed Original ResearchHuman ovarian tissueOvarian tissueAutologous transplantationFrozen-thawed human ovarian tissueOvarian tissue cryopreservationReproductive-age womenPremature ovarian failureOvarian reserveGonadotoxic therapyAntineoplastic treatmentGonadotoxic treatmentFertility preservationOvarian cortexOvarian failureAge womenReproductive surgeryTissue cryopreservationEndocrine functionPrimordial folliclesPrepubertal ageNononcological diseasesTransplantationTreatmentDiseaseTissue
2017
Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage
Kawahara T, Sugishita Y, Taylan E, Suzuki N, Moy F, Oktay K. Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage. Fertility And Sterility 2017, 108: e56-e57. DOI: 10.1016/j.fertnstert.2017.07.179.Peer-Reviewed Original Research
2012
Ovarian cryopreservation.
Jeong K, Aslan E, Ozkaya E, Sonmezer M, Oktay K. Ovarian cryopreservation. Minerva Medica 2012, 103: 37-46. PMID: 22278067.Peer-Reviewed Original ResearchConceptsFertility preservationOvarian tissueNon-malignant diseasesFuture autotransplantationOvarian cryopreservationOvarian failurePrepubertal girlsReproductive endocrinologistsMalignant cellsTeam approachWhole ovariesHeterotopic locationNew promising strategyAutotransplantationSignificant delayDiseaseTissue piecesTissuePromising strategySlow freezingChemotherapyLaparoscopyPatientsEndocrinologistsOncologists
2011
Approach to Fertility Preservation in Adult and Prepubertal Females
Rodriguez-Wallberg K, Oktay K. Approach to Fertility Preservation in Adult and Prepubertal Females. 2011, 233-241. DOI: 10.1007/978-1-4419-1783-6_18.Peer-Reviewed Original ResearchFertility preservationFemale patientsCancer treatmentFemale cancer survivorsAdult female patientsClinical presentationGonadotoxic treatmentCancer survivorsPrepubertal girlsPsychosocial distressPrepubertal femalesPatientsOvarian tissueMost cancersAvailable evidenceInfertilityMain diseaseTreatmentCancerWestern countriesAgeOnly optionOptionsIncidenceDisease
2009
Recurrent spontaneous pregnancies and live births following heterotopic transplantation of frozen banked ovarian tissue despite the absence of follicular activity in the remaining menopausal ovary
Oktay K. Recurrent spontaneous pregnancies and live births following heterotopic transplantation of frozen banked ovarian tissue despite the absence of follicular activity in the remaining menopausal ovary. Fertility And Sterility 2009, 92: s66. DOI: 10.1016/j.fertnstert.2009.07.255.Peer-Reviewed Original Research
2005
Sustained Endocrine Function And Spontaneous Pregnancies After Subcutaneous Transplantation Of Cryopreserved Ovarian Tissue In Stem Cell Transplant Recipients
Oktay K, Oktem O. Sustained Endocrine Function And Spontaneous Pregnancies After Subcutaneous Transplantation Of Cryopreserved Ovarian Tissue In Stem Cell Transplant Recipients. Fertility And Sterility 2005, 84: s68. DOI: 10.1016/j.fertnstert.2005.07.162.Peer-Reviewed Original ResearchOocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications
Shamonki M, Oktay K. Oocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications. Seminars In Reproductive Medicine 2005, 23: 266-276. PMID: 16059833, DOI: 10.1055/s-2005-872455.Peer-Reviewed Original Research
2004
Embryo Development After Heterotopic Transplantation of Cryopreserved Ovarian Tissue
Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, Opsahl M, Rosenwaks Z. Embryo Development After Heterotopic Transplantation of Cryopreserved Ovarian Tissue. Obstetrical & Gynecological Survey 2004, 59: 520-522. DOI: 10.1097/00006254-200407000-00018.Peer-Reviewed Original ResearchOvarian cortical piecesOvarian stimulationCortical piecesOvarian tissueOvarian functionEndocrine functionFollicle-stimulating hormone increaseFrozen-thawed ovarian tissueSequelae of chemotherapyHuman menopausal gonadotropinFollicle-stimulating hormoneOvarian endocrine functionLower abdominal wallRecombinant human chorionic gonadotropinHuman chorionic gonadotropinIntracytoplasmic sperm injectionGonadotoxic chemotherapyMenopausal gonadotropinMost patientsOocyte retrievalOvarian transplantationPremature menopauseOocyte maturityPatient's uterusAbstract Patients
2002
The potential of ovarian tissue transplant to preserve fertility
Buyuk E, Oktay K. The potential of ovarian tissue transplant to preserve fertility. Expert Opinion On Biological Therapy 2002, 2: 361-370. PMID: 11955275, DOI: 10.1517/14712598.2.4.361.Peer-Reviewed Original ResearchConceptsClinical studiesOvarian tissue transplantsSafety of pregnancyFuture clinical trialsPremature ovarian failureOvarian follicle developmentOvarian graftsOvarian cryopreservationOvarian transplantationOvarian functionCancer patientsOvarian failureClinical trialsAnimal studiesTissue transplantsOvarian tissueFurther basic researchHormone productionFollicle developmentRevascularisation processPregnancyPatientsTransplantationWomenSafetyPreliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips
Oktay K, Yih M. Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips. Seminars In Reproductive Medicine 2002, 20: 063-074. PMID: 11941536, DOI: 10.1055/s-2002-23520.Peer-Reviewed Original ResearchConceptsOvarian cortical stripsOvarian transplantationOvarian tissueCortical stripsHeterotopic transplantationAutologous ovarian transplantationFrozen ovarian tissueHeterotopic techniqueNew York surgeonPatient selectionOvarian functionSurgical techniqueTransplantationTransplanted tissuePreliminary experienceExperimental modelOperating roomCancer cellsClinical applicationTissueSafety measuresOrthotopicCliniciansSurgeonsTrounson
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomenRecent progress in oocyte and ovarian tissue cryopreservation and transplantation
Oktay K, Kan M, Rosenwaks Z. Recent progress in oocyte and ovarian tissue cryopreservation and transplantation. Current Opinion In Obstetrics & Gynecology 2001, 13: 263-268. PMID: 11396648, DOI: 10.1097/00001703-200106000-00003.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationOocyte freezingTissue cryopreservationOocyte cryopreservationOvarian tissueOvarian stimulation cyclesGroup of patientsNumber of pregnanciesInstitutional review boardOvarian transplantationAge-related declineOvarian functionStimulation cyclesReproductive surgeryContext of cancerCryopreserved oocytesReproductive functionEmbryo freezingTransplantationReview boardFirst caseInadequate timeSignificant scientific advancesWomenOocytesA technique for laparoscopic transplantation of frozen-banked ovarian tissue
Oktay K, Aydin B, Karlikaya G. A technique for laparoscopic transplantation of frozen-banked ovarian tissue. Fertility And Sterility 2001, 75: 1212-1216. PMID: 11384651, DOI: 10.1016/s0015-0282(01)01776-9.Peer-Reviewed Original ResearchConceptsFrozen-banked ovarian tissueLaparoscopic transplantationOvarian tissueAcademic medical centerSlow-freezing techniqueMenopausal gonadotropinOvarian stimulationSpontaneous mensesOvarian fossaPelvic peritoneumOvarian functionLaparoscopic techniqueOvarian cortexMedical CenterMAIN OUTCOMEMicrosurgical reconstructionProgesterone productionBlood flowFollicle developmentTransplantationPatientsTissueMensesGonadotropinTransplant
2000
Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm
Oktay K, Aydin B, Economos K, Rucinski J. Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm. Fertility And Sterility 2000, 74: s90-s91. DOI: 10.1016/s0015-0282(00)00967-5.Peer-Reviewed Original Research