2024
Trends and regional differences for fertility preservation procedures in women with breast cancer
Turan V, Bedoschi G, Lee D, Barbosa C, de Oliveira R, Sacinti K, Sonmezer M, Lambertini M, Massarotti C, Schaub A, Wang E, Gayete-Lafuente S, Dunlop C, Anderson R, Bang H, Oktay K. Trends and regional differences for fertility preservation procedures in women with breast cancer. Clinical Breast Cancer 2024 PMID: 39428290, DOI: 10.1016/j.clbc.2024.09.011.Peer-Reviewed Original ResearchWomen of reproductive ageFertility preservationBreast cancerTissue cryopreservationYoung womenReproductive ageOvarian tissue cryopreservationFertility preservation methodsNormal ovarian functionOvarian stimulation cyclesFertility preservation proceduresFertility preservation practicesDiagnosed breast cancerOocyte cryopreservationOvarian stimulationTertiary centerMulticenter studyOvarian functionStimulated cyclesParticipating centersRegional time trendsBreastCancerPreservation proceduresChemotherapyUtility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers
Erden M, Gayete-Lafuente S, Vural N, Oktay K. Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers. Obstetrics And Gynecology 2024, 144: 481-492. PMID: 39173181, PMCID: PMC11499045, DOI: 10.1097/aog.0000000000005708.Peer-Reviewed Original ResearchCryopreserved ovarian tissue transplantationOvarian tissue cryopreservationOvarian tissue transplantationTissue cryopreservationAutologous transplantationGynecologic cancerTissue transplantationOutcome of autologous transplantationPreserving ovarian functionCochrane Library databasesOvarian endocrine functionPooled-effect estimatesSystematic reviewRisk-of-bias assessmentOvarian stimulationHematologic malignanciesLonger-term outcomesFertility preservationOvarian functionBreast cancerLibrary databasesTransplantationGraft longevityCancerEndocrine function
2022
Fertility Preservation in Breast Cancer Patients
Marin L, Turan V, Oktay K. Fertility Preservation in Breast Cancer Patients. 2022, 185-198. DOI: 10.1007/978-3-030-47767-7_14.Peer-Reviewed Original ResearchFertility preservation issuesBreast cancerGonadotropin-releasing hormone agonistNovel chemotherapy regimensSafety of pregnancyFertility preservation techniquesBreast cancer survivorsBreast cancer patientsBreast cancer survivalPremature ovarian insufficiencyBreast cancer treatmentChemotherapy regimensOvarian suppressionPremenopausal womenOvarian reserveHormone agonistCancer survivorsCommon malignancyFertility preservationOvarian functionCancer patientsCancer survivalBRCA mutationsSexual dysfunctionFertility risksChapter 17 Approach to Follow Up After Ovarian Transplantation
Pacheco F, Oktay K. Chapter 17 Approach to Follow Up After Ovarian Transplantation. 2022, 177-184. DOI: 10.1016/b978-0-12-823344-3.00015-7.Peer-Reviewed Original ResearchGraft functionOvarian transplantationAcute postoperative phaseImmediate postoperative complicationsMedical specialistsLong-term careWay pregnancyPostoperative complicationsPostoperative periodTransplantation recipientsIVF attemptsPharmacological supportPostoperative phasePregnancy attemptsOvarian functionPreoperative preparationSimple surgeryNumerous medical problemsClose monitoringPatient's diseaseRecurrence riskMedical problemsTransplantationDiseaseMethod of choice
2021
Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data
Oktay K, Marin L, Bedoschi G, Pacheco F, Sugishita Y, Kawahara T, Taylan E, Acosta C, Bang H. Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data. Fertility And Sterility 2021, 117: 181-192. PMID: 34801235, PMCID: PMC8863399, DOI: 10.1016/j.fertnstert.2021.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesCryopreservationExtracellular MatrixFemaleFertility PreservationHumansMeta-Analysis as TopicNeovascularization, PhysiologicOvaryPregnancyPregnancy RateRetrospective StudiesRobotic Surgical ProceduresTissue Culture TechniquesTissue ScaffoldsTransplantation, AutologousYoung AdultConceptsGraft longevityCase seriesOvarian functionLow-dose aspirinOvarian tissue transplantationOvarian cortical piecesLower embryo qualityOocytes/embryosNeonatal outcomesTransdermal estrogenChemotherapy exposureOvarian transplantationCortical piecesMeta-analytic dataLower abdomenHealthy childrenLive birthsMAIN OUTCOMEGraft vascularizationExtracellular matrix scaffoldsOvarian tissueAneuploidy rateFunction returnsEmbryo qualityMeta-analytic update
2018
Ovarian tissue cryopreservation and transplantation
Bedoschi G, Oktay K. Ovarian tissue cryopreservation and transplantation. 2018, 148-152. DOI: 10.1201/9781351141680-19.Peer-Reviewed Original ResearchOvarian tissue cryopreservationOvarian cortical piecesFertility preservationAdvanced treatment strategiesOvarian transplantationCortical piecesOvarian stimulationSurvival outcomesOvarian functionTreatment strategiesTissue cryopreservationAccelerated phaseEarly detectionHeterotopic ovarian transplantationFertility preservation proceduresLower abdominal wallFirst descriptionOvarian endocrineInitial ischemiaOvarian cryopreservationPharmacological supportTransplant proceduresFollicle lossCancer careCancer patients
2015
Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment
Turan V, Oktay K. Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment. 2015, 47-61. DOI: 10.1016/b978-0-12-801591-9.00004-7.Peer-Reviewed Original ResearchCancer treatmentComplications of chemotherapySystemic lupus erythematosusPremature ovarian insufficiencyQuality of lifeOvarian damageLupus erythematosusOvarian toxicityAutoimmune diseasesOvarian functionBRCA mutationsReproductive ageRelative riskChemotherapy agentsClinical dataOvarian insufficiencySurvival rateChemotherapeutic agentsOvarian cellsChemotherapyHuman dataTreatmentCurrent understandingErythematosusComplicationsOvarian Tissue Cryopreservation: Where Are We Now?
Bedoschi G, Oktay K. Ovarian Tissue Cryopreservation: Where Are We Now? 2015, 71-78. DOI: 10.1007/978-3-319-17849-3_6.Peer-Reviewed Original ResearchFertility preservationOvarian stimulationOvarian cortical piecesAdvanced treatment strategiesPre-pubertal childrenOvarian cryopreservationCortical piecesSurvival outcomesOvarian functionCancer careCancer patientsTreatment strategiesEndocrine functionOocyte cryopreservationAccelerated phaseEarly detectionCancer communityPatientsTransplantationFirst descriptionStimulationSufficient time periodChemotherapySuccessful restorationCancer
2012
Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease
2004
Embryo Development After Heterotopic Transplantation of Cryopreserved Ovarian Tissue
Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, Opsahl M, Rosenwaks Z. Embryo Development After Heterotopic Transplantation of Cryopreserved Ovarian Tissue. Obstetrical & Gynecological Survey 2004, 59: 520-522. DOI: 10.1097/00006254-200407000-00018.Peer-Reviewed Original ResearchOvarian cortical piecesOvarian stimulationCortical piecesOvarian tissueOvarian functionEndocrine functionFollicle-stimulating hormone increaseFrozen-thawed ovarian tissueSequelae of chemotherapyHuman menopausal gonadotropinFollicle-stimulating hormoneOvarian endocrine functionLower abdominal wallRecombinant human chorionic gonadotropinHuman chorionic gonadotropinIntracytoplasmic sperm injectionGonadotoxic chemotherapyMenopausal gonadotropinMost patientsOocyte retrievalOvarian transplantationPremature menopauseOocyte maturityPatient's uterusAbstract Patients
2002
The potential of ovarian tissue transplant to preserve fertility
Buyuk E, Oktay K. The potential of ovarian tissue transplant to preserve fertility. Expert Opinion On Biological Therapy 2002, 2: 361-370. PMID: 11955275, DOI: 10.1517/14712598.2.4.361.Peer-Reviewed Original ResearchConceptsClinical studiesOvarian tissue transplantsSafety of pregnancyFuture clinical trialsPremature ovarian failureOvarian follicle developmentOvarian graftsOvarian cryopreservationOvarian transplantationOvarian functionCancer patientsOvarian failureClinical trialsAnimal studiesTissue transplantsOvarian tissueFurther basic researchHormone productionFollicle developmentRevascularisation processPregnancyPatientsTransplantationWomenSafetyPreliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips
Oktay K, Yih M. Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips. Seminars In Reproductive Medicine 2002, 20: 063-074. PMID: 11941536, DOI: 10.1055/s-2002-23520.Peer-Reviewed Original ResearchConceptsOvarian cortical stripsOvarian transplantationOvarian tissueCortical stripsHeterotopic transplantationAutologous ovarian transplantationFrozen ovarian tissueHeterotopic techniqueNew York surgeonPatient selectionOvarian functionSurgical techniqueTransplantationTransplanted tissuePreliminary experienceExperimental modelOperating roomCancer cellsClinical applicationTissueSafety measuresOrthotopicCliniciansSurgeonsTrounson
2001
Recent progress in oocyte and ovarian tissue cryopreservation and transplantation
Oktay K, Kan M, Rosenwaks Z. Recent progress in oocyte and ovarian tissue cryopreservation and transplantation. Current Opinion In Obstetrics & Gynecology 2001, 13: 263-268. PMID: 11396648, DOI: 10.1097/00001703-200106000-00003.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationOocyte freezingTissue cryopreservationOocyte cryopreservationOvarian tissueOvarian stimulation cyclesGroup of patientsNumber of pregnanciesInstitutional review boardOvarian transplantationAge-related declineOvarian functionStimulation cyclesReproductive surgeryContext of cancerCryopreserved oocytesReproductive functionEmbryo freezingTransplantationReview boardFirst caseInadequate timeSignificant scientific advancesWomenOocytesA technique for laparoscopic transplantation of frozen-banked ovarian tissue
Oktay K, Aydin B, Karlikaya G. A technique for laparoscopic transplantation of frozen-banked ovarian tissue. Fertility And Sterility 2001, 75: 1212-1216. PMID: 11384651, DOI: 10.1016/s0015-0282(01)01776-9.Peer-Reviewed Original ResearchConceptsFrozen-banked ovarian tissueLaparoscopic transplantationOvarian tissueAcademic medical centerSlow-freezing techniqueMenopausal gonadotropinOvarian stimulationSpontaneous mensesOvarian fossaPelvic peritoneumOvarian functionLaparoscopic techniqueOvarian cortexMedical CenterMAIN OUTCOMEMicrosurgical reconstructionProgesterone productionBlood flowFollicle developmentTransplantationPatientsTissueMensesGonadotropinTransplant
2000
Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm
Oktay K, Aydin B, Economos K, Rucinski J. Restoration of Ovarian Function After Autologous Transplantation of Human Ovarian Tissue in the Forearm. Fertility And Sterility 2000, 74: s90-s91. DOI: 10.1016/s0015-0282(00)00967-5.Peer-Reviewed Original Research