2024
The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Suzuki R, Tan X, Szymanska K, Kubikova N, Perez C, Wells D, Oktay K. The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging. Cell Death Discovery 2024, 10: 302. PMID: 38914566, PMCID: PMC11196715, DOI: 10.1038/s41420-024-02041-z.Peer-Reviewed Original ResearchOocyte qualityAtaxia telangiectasia-mutatedOocyte agingMaintenance of oocyte qualityDNA double-strand breaksMeiosis in vitroPoor embryo developmentImpaired oocyte qualityATM functionMolecular cytogenetic analysisFormation of DNA DSBsDeath compared to controlsBlastocyst stageEmbryo cleavageDNA DSBsOvarian agingCytogenetic analysisResistance to genotoxic stressActive metaboliteNext-generation sequencingRates compared to controlsIn vitro cultureOocytesDNA DSB repairAge-induced declineModeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2000
New Strategies in Studying Ovarian Aging
Oktay K, Karlikaya G, Bayrakceken A. New Strategies in Studying Ovarian Aging. Serono Symposia USA 2000, 80-88. DOI: 10.1007/978-0-387-21628-7_8.Peer-Reviewed Original Research