2024
Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2022
Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause
Oktay K, Marin L. Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause. 2022, 193-201. DOI: 10.1016/b978-0-12-823344-3.00003-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationHealthy womenTissue cryopreservationOvarian tissue harvestingOvarian tissue freezingRisk-benefit assessmentOvarian cryopreservationClinical guidelinesReproductive yearsAmount of tissueMedical indicationsReproductive agingTransplantation techniquesTissue harvestingMenopauseTransplantationWomenTissue freezingCryopreservation
2021
DOES HARVESTING OVARIAN TISSUE TO DELAY REPRODUCTIVE AGING HAVE A NEGATIVE IMPACT ON THE NATURAL AGE OF MENOPAUSE IN HEALTHY WOMEN?
Petrikovsky B, Marin L, Oktay K. DOES HARVESTING OVARIAN TISSUE TO DELAY REPRODUCTIVE AGING HAVE A NEGATIVE IMPACT ON THE NATURAL AGE OF MENOPAUSE IN HEALTHY WOMEN? Fertility And Sterility 2021, 116: e9. DOI: 10.1016/j.fertnstert.2021.07.032.Peer-Reviewed Original ResearchDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantation
1998
Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology?
Oktay K, Newton H, Aubard Y, Salha O, G.Gosden R. Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology? Fertility And Sterility 1998, 69: 1-7. PMID: 9457923, DOI: 10.1016/s0015-0282(97)00207-0.Peer-Reviewed Original ResearchConceptsOvarian tissueConservation of fertilityHigh-dose chemotherapyOvarian tissue cryopreservationImmature human oocytesOvarian biopsy samplesOvarian tissue bankingNeeds of patientsLong-term survivorshipCryopreservation of oocytesHealthy womenOvarian stromaImmature folliclesTissue cryopreservationPrimordial folliclesBiopsy samplesFollicle growthNeedy patientsImmature oocytesPatientsHuman oocytesDisappointing resultsOocyte fertilityReproductive optionsFollicles
1997
Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue
Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden R. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertility And Sterility 1997, 67: 481-486. PMID: 9091334, DOI: 10.1016/s0015-0282(97)80073-8.Peer-Reviewed Original ResearchConceptsHuman ovarian tissuePrimordial folliclesOvarian tissueWhole folliclesElective cesarean sectionLeeds General InfirmaryCryopreserved ovarian tissueHuman primordial folliclesCesarean sectionHealthy womenOvarian biopsyFollicle countingGeneral InfirmaryMAIN OUTCOMEFollicle viabilityUltrastructural signsFrozen-thawed groupFolliclesFresh groupTissuePropidium iodideSuccinimidyl esterViability ratePercent viabilityOocytes