2024
Classification of Human Ovarian Follicle Morphology: Recommendations of the NICHD-Sponsored Ovarian Nomenclature Workshop
Yano Maher J, Zelinski M, Oktay K, Duncan F, Segars J, Lujan M, Lou H, Yun B, Hanfling S, Schwartz L, Laronda M, Halvorson L, O'Neill K, Gomez-Lobo V. Classification of Human Ovarian Follicle Morphology: Recommendations of the NICHD-Sponsored Ovarian Nomenclature Workshop. Fertility And Sterility 2024 PMID: 39549739, DOI: 10.1016/j.fertnstert.2024.11.016.Peer-Reviewed Original ResearchPreantral folliclesAntral folliclesWorking subgroupEunice Kennedy Shriver National Institute of Child HealthNormal antral folliclesAntral follicle stageNational Institute of Child HealthInstitute of Child HealthPre-ovulatory folliclesPreantral stageAbnormal oocytesFollicle stageGranulosa cellsCorpora luteaFolliclesFollicle typesHuman fertilitySubgroupsFollicle densityAssessed changesCliniciansChild healthNICHDGranulosaOvarian
2012
Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease
2008
Comparison of predictive value of anti-mullerian hormone (AMH) and day 3 follicle stimulating hormone for pregnancy and oocyte retrieval
Barad D, Oktay K, Weghofer A, Gleicher N. Comparison of predictive value of anti-mullerian hormone (AMH) and day 3 follicle stimulating hormone for pregnancy and oocyte retrieval. Fertility And Sterility 2008, 90: s473. DOI: 10.1016/j.fertnstert.2008.07.171.Peer-Reviewed Original ResearchAnti-mullerian hormone (AMH), but not follicle stimulating hormone (FSH), correlates to oocyte yield in in vitro fertilization
Barad D, Oktay K, Weghofer A, Gleicher N. Anti-mullerian hormone (AMH), but not follicle stimulating hormone (FSH), correlates to oocyte yield in in vitro fertilization. Fertility And Sterility 2008, 90: s259-s260. DOI: 10.1016/j.fertnstert.2008.07.1228.Peer-Reviewed Original Research
2000
Ovarian cryopreservation and transplantation: basic aspects
Oktay K, Karlikaya G, Aydin B. Ovarian cryopreservation and transplantation: basic aspects. Molecular And Cellular Endocrinology 2000, 169: 105-108. PMID: 11155939, DOI: 10.1016/s0303-7207(00)00361-0.Peer-Reviewed Original ResearchInteraction of Extracellular Matrix and Activin-A in the Initiation of Follicle Growth in the Mouse Ovary1
Oktay K, Karlikaya G, Akman O, Ojakian G, Oktay M. Interaction of Extracellular Matrix and Activin-A in the Initiation of Follicle Growth in the Mouse Ovary1. Biology Of Reproduction 2000, 63: 457-461. PMID: 10906050, DOI: 10.1095/biolreprod63.2.457.Peer-Reviewed Original ResearchConceptsFollicle growth initiationFollicle developmentFollicle growthFollicle growth rateFollicle densityRecombinant human activinEarly follicle developmentEarly follicular developmentRole of activinAbsence of activinTotal folliclesFollicular growthExtracellular matrixFollicular developmentTreatment groupsMultilayer folliclesMouse ovariesActivin treatmentHuman activinPresence of lamininActivinExtracellular matrix componentsPrecise mechanismMiceFolliclesTransplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice
Oktay K, Newton H, Gosden R. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertility And Sterility 2000, 73: 599-603. PMID: 10689020, DOI: 10.1016/s0015-0282(99)00548-8.Peer-Reviewed Original ResearchConceptsOvarian tissueSCID miceFrozen-thawed human ovarian tissueFrozen-thawed ovarian tissueAutologous ovarian transplantationFrozen-thawed graftsHuman ovarian tissueFollicle growth initiationLong-term survivalWeeks of graftingHuman primordial folliclesFollicle countOvarian transplantationImmunodeficiency miceMAIN OUTCOMEHealthy folliclesPrimordial folliclesAcademic centersAnimal studiesFollicle stageAdvanced folliclesFolliclesGraftMiceNecrotic cellsNew Strategies in Studying Ovarian Aging
Oktay K, Karlikaya G, Bayrakceken A. New Strategies in Studying Ovarian Aging. Serono Symposia USA 2000, 80-88. DOI: 10.1007/978-0-387-21628-7_8.Peer-Reviewed Original Research
1998
Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology?
Oktay K, Newton H, Aubard Y, Salha O, G.Gosden R. Cryopreservation of immature human oocytes and ovarian tissue: An emerging technology? Fertility And Sterility 1998, 69: 1-7. PMID: 9457923, DOI: 10.1016/s0015-0282(97)00207-0.Peer-Reviewed Original ResearchConceptsOvarian tissueConservation of fertilityHigh-dose chemotherapyOvarian tissue cryopreservationImmature human oocytesOvarian biopsy samplesOvarian tissue bankingNeeds of patientsLong-term survivorshipCryopreservation of oocytesHealthy womenOvarian stromaImmature folliclesTissue cryopreservationPrimordial folliclesBiopsy samplesFollicle growthNeedy patientsImmature oocytesPatientsHuman oocytesDisappointing resultsOocyte fertilityReproductive optionsFollicles
1997
Ontogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles
Oktay K. Ontogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 3748-3751. DOI: 10.1210/jc.82.11.3748.Peer-Reviewed Original ResearchOntogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles1
Oktay K, Briggs D, Gosden R. Ontogeny of Follicle-Stimulating Hormone Receptor Gene Expression in Isolated Human Ovarian Follicles1. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 3748-3751. PMID: 9360535, DOI: 10.1210/jcem.82.11.4346.Peer-Reviewed Original ResearchConceptsMessenger ribonucleic acidPrimordial folliclesFollicle stageElective cesarean sectionHuman ovarian folliclesPreantral follicle developmentFSH receptor geneHormone receptor gene expressionReceptor gene expressionFollicle-stimulating hormone receptor gene expressionCesarean sectionRectus muscleHuman ovaryAntral folliclesFollicular growthFSH expressionHuman folliculogenesisOvarian folliclesOvarian tissueGranulosa cellsMultilaminar folliclesStromal tissueSingle follicleFollicle developmentFolliclesIsolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue
Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden R. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertility And Sterility 1997, 67: 481-486. PMID: 9091334, DOI: 10.1016/s0015-0282(97)80073-8.Peer-Reviewed Original ResearchConceptsHuman ovarian tissuePrimordial folliclesOvarian tissueWhole folliclesElective cesarean sectionLeeds General InfirmaryCryopreserved ovarian tissueHuman primordial folliclesCesarean sectionHealthy womenOvarian biopsyFollicle countingGeneral InfirmaryMAIN OUTCOMEFollicle viabilityUltrastructural signsFrozen-thawed groupFolliclesFresh groupTissuePropidium iodideSuccinimidyl esterViability ratePercent viabilityOocytes
1996
Follicle freezing and autografting. A new method of medically assisted procreation?.
Aubard Y, Newton H, Oktay K, Piver P, Gosden R. Follicle freezing and autografting. A new method of medically assisted procreation?. La Presse Médicale 1996, 25: 921-3. PMID: 8685154.Peer-Reviewed Original ResearchConceptsOvulatory capacityHuman folliclePrimordial folliclesQuantity of folliclesUse of allograftsLarge animal modelImmunosuppressive therapyDestructive therapySuccessful treatmentOvarian fragmentsSurvival timeAnimal modelsOvarian tissueFollicular tissueFolliclesExperimental modelTherapyAge limitTissueHuman tissuesOvocytesEncouraging resultsOptimal siteReimplantationAllograftsDiminished α-inhibin messenger ribonucleic acid in in vitro fertilization-embryo transfer poor responders reflects declining follicle reserve**Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994.
Burns W, Oktay K, Tekmal R, Nelson J, Schenken R. Diminished α-inhibin messenger ribonucleic acid in in vitro fertilization-embryo transfer poor responders reflects declining follicle reserve**Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. Fertility And Sterility 1996, 65: 394-399. PMID: 8566269, DOI: 10.1016/s0015-0282(16)58106-0.Peer-Reviewed Original ResearchConceptsPoor respondersGood respondersMessenger RNA levelsOvarian responsivenessIVF-ETMRNA levelsPg/Academic tertiary care institutionGranulosa cell samplesRNA levelsDay of hCGTertiary care institutionGranulosa cell functionTotal mRNAGynecologic InvestigationFollicle numberFollicle aspirationE2 concentrationsMessenger ribonucleic acidRespondersFolliclesCare institutionsCell functionDecreased poolRecent reports
1995
Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1
Oktay K, Schenken R, Nelson J. Proliferating Cell Nuclear Antigen Marks the Initiation of Follicular Growth in the Rat1. Biology Of Reproduction 1995, 53: 295-301. PMID: 7492681, DOI: 10.1095/biolreprod53.2.295.Peer-Reviewed Original ResearchConceptsPCNA expressionPrimary folliclesFollicle growthCell nuclear antigenAntral folliclesFollicular growthPCNA immunoreactivityGranulosa cellsNuclear antigenEarly primary folliclesGranulosa cell layerTransitional folliclesControl ratsAdult ratsPrimordial folliclesSensitive markerPCNA stainingAtretic folliclesRat ovaryOocyte enlargementProliferating Cell Nuclear AntigenEarly signsFolliclesParaffin sectionsPregranulosa cells