2024
Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2021
Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation
Titus S, Szymanska K, Musul B, Turan V, Taylan E, Garcia- Milian R, Mehta S, Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Scientific Reports 2021, 11: 407. PMID: 33431979, PMCID: PMC7801500, DOI: 10.1038/s41598-020-79643-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCyclophosphamideDNA DamageFemaleGene Expression ProfilingHeterograftsHumansMiceMice, Inbred NODMice, SCIDOocytesOogenesisOvarian FollicleOvarian ReserveOvarySignal TransductionSingle-Cell AnalysisTranscriptomeYoung AdultConceptsPrimordial follicle oocytesFollicle lossGrowth activationHuman ovarian xenograft modelPI3K/PTEN/AktFollicle oocytesDNA damagePI3K/PTEN/Akt pathwayOvarian reserve depletionPrimordial follicle reservePTEN/AKT pathwayIngenuity Pathway AnalysisOvarian xenograft modelPTEN/AKTSevere DNA damageExpression of AktGonadotoxic chemotherapyAnti-apoptotic Bcl2Early menopauseFollicle reserveTranscriptomic analysisCyclophosphamide injectionHuman ovaryPhosphorylation statusRNA sequencing
2018
Ovarian tissue cryopreservation and transplantation
Bedoschi G, Oktay K. Ovarian tissue cryopreservation and transplantation. 2018, 148-152. DOI: 10.1201/9781351141680-19.Peer-Reviewed Original ResearchOvarian tissue cryopreservationOvarian cortical piecesFertility preservationAdvanced treatment strategiesOvarian transplantationCortical piecesOvarian stimulationSurvival outcomesOvarian functionTreatment strategiesTissue cryopreservationAccelerated phaseEarly detectionHeterotopic ovarian transplantationFertility preservation proceduresLower abdominal wallFirst descriptionOvarian endocrineInitial ischemiaOvarian cryopreservationPharmacological supportTransplant proceduresFollicle lossCancer careCancer patients
2007
A novel xenograft model to test the ovarian toxicity of chemotherapy agents in women
Oktay K, Oktem O. A novel xenograft model to test the ovarian toxicity of chemotherapy agents in women. Journal Of Clinical Oncology 2007, 25: 19504-19504. DOI: 10.1200/jco.2007.25.18_suppl.19504.Peer-Reviewed Original ResearchXenograft modelFollicle lossClinical trialsChemotherapy agentsHuman ovarian xenograft modelPrimordial follicle countsNovel xenograft modelOvarian xenograft modelOvarian reserveFollicle countMice 12Ovarian toxicityCY injectionGonadotoxic effectsPremenopausal femalesSingle doseHuman ovaryOvarian piecesClinical studiesImmunodeficient miceSingle injectionNew agentsOvarian histologyXenograft vasculatureTUNEL staining