2011
Regulation of human osteoclast development by dendritic cell‐specific transmembrane protein (DC‐STAMP)
Chiu Y, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. Regulation of human osteoclast development by dendritic cell‐specific transmembrane protein (DC‐STAMP). Journal Of Bone And Mineral Research 2011, 27: 79-92. PMID: 21987375, PMCID: PMC3304467, DOI: 10.1002/jbmr.531.Peer-Reviewed Original ResearchConceptsDendritic cell-specific transmembrane proteinImmunoreceptor tyrosine-based inhibitory motifOC precursorsInflammatory arthritisTransmembrane proteinSH2 domain-containing tyrosine phosphataseTransmembrane receptor-like proteinErosive inflammatory arthritisCell fusionTumor giant cellsMetabolic bone diseaseReceptor-like proteinDC-STAMP expressionTyrosine-based inhibitory motifCell surface receptorsBone diseaseHuman PBMCsTyrosine phosphataseOsteoclast developmentCytoplasmic tailGiant cellsCellular transformationOC formationOsteoclastogenesisSHP-1
2009
RANKL induces heterogeneous DC‐STAMPlo and DC‐STAMPhi osteoclast precursors of which the DC‐STAMPlo precursors are the master fusogens
Mensah KA, Ritchlin CT, Schwarz EM. RANKL induces heterogeneous DC‐STAMPlo and DC‐STAMPhi osteoclast precursors of which the DC‐STAMPlo precursors are the master fusogens. Journal Of Cellular Physiology 2009, 223: 76-83. PMID: 20039274, PMCID: PMC2814997, DOI: 10.1002/jcp.22012.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAnimalsAntigens, CDBiomarkersBlotting, WesternBone Marrow CellsCD47 AntigenCell DifferentiationCell FusionCells, CulturedFlow CytometryImmunoproliferative DisordersIsoenzymesMacrophagesMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred C57BLMicroscopy, FluorescenceNerve Tissue ProteinsOsteoclastsPhenotypeProtein MultimerizationRANK LigandReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStem CellsTartrate-Resistant Acid PhosphataseTetraspanin 29Time FactorsConceptsOC precursorsDC-STAMPFlow cytometryUnique surface markersMetabolic bone diseaseRANKL-induced osteoclastogenesisThe emerging field of osteoimmunology
Mensah KA, Li J, Schwarz EM. The emerging field of osteoimmunology. Immunologic Research 2009, 45: 100-113. PMID: 19184540, PMCID: PMC2934875, DOI: 10.1007/s12026-009-8093-x.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisAdaptive immune effector cellsImmune effector cellsTreatment of autoimmuneField of osteoimmunologyMetabolic bone diseaseSkeletal systemImmune cell ontogenySubsequent effector functionsBasic science findingsEffector cellsAutoimmune diseasesInflammatory diseasesBone diseaseEffector functionsBone microenvironmentBiologic drugsDiseaseCell ontogenyBone biologyClinical applicationEffector moleculesOsteoimmunologyRecent findingsRecent studies