2024
Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation
Ranjan K, Pathak C. Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation. International Journal Of Molecular Sciences 2024, 25: 3228. PMID: 38542202, PMCID: PMC10970579, DOI: 10.3390/ijms25063228.Peer-Reviewed Original ResearchConceptsFas-associated death domainDeath domainDeath receptorsInitiation of apoptotic signalingRegulate programmed cell deathExpression of Fas-associated death domainSignaling pathwayCellular dynamicsRegulator of inflammatory signalingRegulation of cancerAdaptor proteinActivated caspasesApoptotic functionApoptosis signalingSubcellular localizationApoptotic signalingCellular homeostasisCell deathCell survivalCoordinated removalCellular senescenceIntracellular expressionCell proliferationSpatiotemporal mechanismsInflammatory signaling
2016
Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death
Ranjan K, Pathak C. Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death. Molecular And Cellular Biochemistry 2016, 422: 135-150. PMID: 27619661, DOI: 10.1007/s11010-016-2813-z.Peer-Reviewed Original ResearchConceptsExpression of FADDMitochondrial integrityCell deathDeath receptorsMutant of FADDInduced expressionNon-apoptotic functionsDeath receptor signalingFate of cellsMitochondrial-associated apoptosisApoptotic cell deathCancer cellsCellular signalingEctopic expressionJNK1 activationFADDCellular respirationHA14-1Independent pathwaysReceptor signalingCFLIPCFLIPLBcl-2ApoptosisIntracellular ROS
2012
Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells
Ranjan K, Surolia A, Pathak C. Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. Journal Of Cell Communication And Signaling 2012, 6: 155-168. PMID: 22791313, PMCID: PMC3421020, DOI: 10.1007/s12079-012-0166-2.Peer-Reviewed Original ResearchFas-associated death domainHEK 293T cellsDeath effector domainDeath receptorsDeath domainProcaspase-8Anti-apoptotic protein cFLIPExecution of apoptosisFADD protein expressionCommon adaptor moleculeAnti-apoptotic proteinsDED motifsInduction of apoptosisEffector domainExtrinsic caspaseInhibition of apoptosisElevated intracellular levelsAdaptor moleculeCell survivalCFLIPApoptotic potentialApoptosisCell proliferationElevated expressionIntracellular levels