2016
Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress
Ranjan K, Pathak C. Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress. Journal Of Cellular Biochemistry 2016, 117: 1757-1768. PMID: 26682748, DOI: 10.1002/jcb.25474.Peer-Reviewed Original ResearchConceptsAutophagic stressDependent ubiquitinationBeclin-1Bcl-2Cell deathExpression of cFLIPLCo-immunoprecipitation analysisRegulation of autophagyHEK 293T cellsDifferent physiological processesAnti-apoptotic proteinsCellular homeostasisCellular stressEctopic expressionKnockdown cellsJNK1 activationCanonical interactionsProtein HMGB1Physiological processesBasal interactionCFLIPLSelective knockdownUbiquitinationAutophagyH2 O2
2012
Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells
Ranjan K, Surolia A, Pathak C. Apoptotic potential of Fas‐associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. Journal Of Cell Communication And Signaling 2012, 6: 155-168. PMID: 22791313, PMCID: PMC3421020, DOI: 10.1007/s12079-012-0166-2.Peer-Reviewed Original ResearchFas-associated death domainHEK 293T cellsDeath effector domainDeath receptorsDeath domainProcaspase-8Anti-apoptotic protein cFLIPExecution of apoptosisFADD protein expressionCommon adaptor moleculeAnti-apoptotic proteinsDED motifsInduction of apoptosisEffector domainExtrinsic caspaseInhibition of apoptosisElevated intracellular levelsAdaptor moleculeCell survivalCFLIPApoptotic potentialApoptosisCell proliferationElevated expressionIntracellular levels