2006
Ventilator-Associated Pneumonia After Combined Burn and Trauma Is Caused by Associated Injuries and Not the Burn Wound
Eckert MJ, Wade TE, Davis KA, Luchette FA, Esposito TJ, Poulakidas SJ, Santaniello JM, Gamelli RL. Ventilator-Associated Pneumonia After Combined Burn and Trauma Is Caused by Associated Injuries and Not the Burn Wound. Journal Of Burn Care & Research 2006, 27: 457-462. PMID: 16819348, DOI: 10.1097/01.bcr.0000226034.84068.cf.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaIndependent risk factorTime of intubationED intubationInitial EDUrgent intubationInhalation injuryAssociated injuriesBurn centerRisk factorsTraumatic injuryDiagnosis of VAPIntensive care unit lengthSubsequent ventilator-associated pneumoniaLevel I trauma centerVerified burn centerI trauma centerMajority of patientsOccurrence of pneumoniaTrauma registry dataEmergency department settingCombined burnTBSA burnHospital daysRetrospective review
2004
Ten Year Experience of Burn, Trauma, and Combined Burn/Trauma Injuries Comparing Outcomes
Santaniello JM, Luchette FA, Esposito TJ, Gunawan H, Reed RL, Davis KA, Gamelli RL. Ten Year Experience of Burn, Trauma, and Combined Burn/Trauma Injuries Comparing Outcomes. Journal Of Trauma And Acute Care Surgery 2004, 57: 696-701. PMID: 15514521, DOI: 10.1097/01.ta.0000140480.50079.a8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAgedBurn UnitsBurnsBurns, InhalationCause of DeathChildCombined Modality TherapyCritical CareFemaleFollow-Up StudiesHumansInjury Severity ScoreLogistic ModelsMaleMiddle AgedMultiple TraumaMultivariate AnalysisPredictive Value of TestsRegistriesRetrospective StudiesRisk AssessmentSex DistributionSurvival AnalysisTrauma CentersTreatment OutcomeConceptsInjury Severity ScoreNational Trauma Data BankLength of stayNational Burn RepositoryInhalation injuryIndependent predictorsMultiple logistic regressionInjury patternsPercent total body surface area burnsTotal body surface area burnsBody surface area burnsLogistic regressionT patientsBurn/traumaRare injury patternSurface area burnsTrauma Data BankT-testStudent's t-testTrauma patientsRetrospective reviewTrauma registryPatient populationComparing outcomesSeverity scoreBurn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model
Davis KA, Santaniello JM, He LK, Muthu K, Sen S, Jones SB, Gamelli RL, Shankar R. Burn Injury and Pulmonary Sepsis: Development of a Clinically Relevant Model. Journal Of Trauma And Acute Care Surgery 2004, 56: 272-278. PMID: 14960967, DOI: 10.1097/01.ta.0000108995.64133.90.Peer-Reviewed Original ResearchConceptsColony-stimulating factorPulmonary sepsisCytokine tumor necrosisSystemic sepsisInterleukin-6Tumor necrosisProinflammatory cytokine tumor necrosisInflammatory cytokine tumor necrosisAlveolar macrophage releaseBurn/traumaDorsal scald burnGram stainMultiple organ failureDevelopment of pneumoniaGranulocyte-macrophage (GM) CSFFemoral bone marrow cellsEnd-organ responseIsolated alveolar macrophagesPositive tissue culturesPseudomonas aeruginosaWhole lung tissueMale B6D2F1 miceTissue Gram stainMacrophage colony-stimulating factorBone marrow cells