2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding
2018
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective
Glover V, O'Donnell KJ, O'Connor TG, Fisher J. Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective. Development And Psychopathology 2018, 30: 843-854. PMID: 30068411, DOI: 10.1017/s095457941800038x.BooksMeSH KeywordsAnxiety DisordersBrainChildCross-Cultural ComparisonDepressive DisorderDeveloping CountriesFemaleFetal DevelopmentHumansHypothalamo-Hypophyseal SystemInfantMental DisordersPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsPsychopathologyPsychosocial DeprivationRisk FactorsSocial EnvironmentStress, PsychologicalConceptsPrenatal stressLater psychopathologyPregnancy-specific anxietyPrenatal maternal stressPrenatal stress altersAdrenal axisChild neurodevelopmentHigh-income countriesFetal programmingInfant deathMaternal stressGene-environment interactionsNutritional deficienciesMothers' stressDifferent ethnic groupsStress altersPsychopathologyBiological differencesEthnic groupsInterpersonal violenceAnxietyCaucasian samplesHigh levelsPregnancyCytokines
2014
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChild AbuseChild, PreschoolDevelopmental DisabilitiesEpigenesis, GeneticHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemConceptsExpression of genesParent-offspring interactionsEpigenetic stateEpigenetic mechanismsEpigenetic programmingEpigenetic studiesStress responseGenesNonhuman speciesAdrenal functionExpressionSpeciesEarly life adversityEarly childhood adversityLater riskFuture studiesChildhood adversityLife adversityFunctionSocial adversityAltersCortisol awakening response and subsequent depression: prospective longitudinal study
Carnegie R, Araya R, Ben-Shlomo Y, Glover V, O'Connor TG, O'Donnell KJ, Pearson R, Lewis G. Cortisol awakening response and subsequent depression: prospective longitudinal study. The British Journal Of Psychiatry 2014, 204: 137-143. PMID: 24311550, PMCID: PMC3909839, DOI: 10.1192/bjp.bp.113.126250.Peer-Reviewed Original ResearchConceptsCortisol awakening responseSubsequent depressionSalivary cortisolAwakening responseOdds ratioTime pointsICD-10 criteriaLongitudinal studyProspective longitudinal studyAvon Longitudinal StudyShort-term riskSubsequent depressive illnessLarge population cohortAdrenal functionDepressive illnessClinical significancePopulation cohortElevated cortisolCortisolLogistic regressionCortisol measuresStress reactivityDepressionDiurnal dropAssociation
2013
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort
2009
Prenatal stress and the programming of the HPA axis
Glover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAnimalsFemaleHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsConceptsHPA axisPrenatal stressLong-term effectsIndependent prospective studiesHPA axis responseBasal cortisol levelsProspective studyAxis responseAnimal studiesCognitive alterationsCortisol responseCortisol levelsCognitive outcomesOutcomesRecent studiesGenetic strainsChildrenLittle evidenceOffspringGestationStudyPrenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta
O’Donnell K, O’Connor T, Glover V. Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta. Developmental Neuroscience 2009, 31: 285-292. PMID: 19546565, DOI: 10.1159/000216539.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisMaternal stressPrenatal stressAnimal studiesMaternal HPA axisAdverse neurodevelopmental outcomesRecent human studiesPartner relationship problemsNeurodevelopmental outcomesFetal exposureFetal neurodevelopmentMaternal cortisolHuman studiesPrenatal stressorsPlacentaBehavioral problemsMaternal environmentCortisolNeurodevelopmentChildrenRelationship problemsAnxietySimilar mechanismPregnancyMixed results