2022
Obesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.Peer-Reviewed Original ResearchConceptsBody mass indexHigh-risk cohortHigher ageHigher body mass indexOngoing prospective studyBlood cell countChild Health StudyEpigenetic agingHigh-risk childrenPoor health outcomesMiddle-aged adultsMass indexProspective studyFuture morbidityBlood leukocytesMortality riskHealth StudyObesityHealth outcomesCell countCohortEarly lifeContinuous variablesChildrenBiological aging
2009
Prenatal stress and the programming of the HPA axis
Glover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisPrenatal stressLong-term effectsIndependent prospective studiesHPA axis responseBasal cortisol levelsProspective studyAxis responseAnimal studiesCognitive alterationsCortisol responseCortisol levelsCognitive outcomesOutcomesRecent studiesGenetic strainsChildrenLittle evidenceOffspringGestationStudy