1999
Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles
Palmatier M, Kang A, Kidd K. Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biological Psychiatry 1999, 46: 557-567. PMID: 10459407, DOI: 10.1016/s0006-3223(99)00098-0.Peer-Reviewed Original ResearchConceptsRestriction site polymorphismsSingle nucleotide polymorphismsAllele frequenciesDifferent population frequenciesControl allele frequenciesEnzyme activity levelsAncestral alleleCandidate genesPopulation-based association studyAssociation studiesSite polymorphismFirst global surveyNucleotide polymorphismsAllelesEnzyme activityPopulation frequencyPolymorphismDifferent populationsCOMT enzyme activityActivity alleleLow-activity alleleGenesProteinGlobal variationPopulation
1998
Analyses of Cross Species Polymerase Chain Reaction Products to Infer the Ancestral State of Human Polymorphisms
Iyengar S, Seaman M, Deinard A, Rosenbaum H, Sirugo G, Castiglione C, Kidd J, Kidd K. Analyses of Cross Species Polymerase Chain Reaction Products to Infer the Ancestral State of Human Polymorphisms. Mitochondrial DNA Part A 1998, 8: 317-327. PMID: 10993602, DOI: 10.3109/10425179809034076.Peer-Reviewed Original ResearchConceptsSingle-strand conformational polymorphismSequence dataUntranslated regionHuman polymorphismsSingle ancestral allelePolymorphic allelesRestriction enzyme sitesAncestral stateExtant populationsGenomic regionsAncestral statusAncestral onesAncestral alleleHuman sequenceHuman allelesStrand conformational polymorphismPCR-RFLPsRestriction fragment length analysisPolymorphic sitesNumerous populationsEnzyme sitesAllelesSpeciesConformational polymorphismPolymerase chain reaction products