2020
Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients
Koch K, Goffredo P, Hrabe J, Gribovskaja-Rupp I, Snow A, Bellizzi A, Kapadia M. Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients. The American Journal Of Surgery 2020, 222: 408-412. PMID: 33317812, DOI: 10.1016/j.amjsurg.2020.12.017.Peer-Reviewed Original ResearchConceptsExtended resectionGenetic counselingResection extentColorectal cancerLynch syndromeCRC specimensMMR deficiencySingle-institution retrospective reviewMMR-deficient patientsSurgical resection extentColorectal cancer patientsMLH1 promoter hypermethylationMismatch repair deficiencyLynch syndrome diagnosisMMR testingRetrospective reviewSegmental resectionSurgical managementCancer patientsLS patientsPatientsResectionSyndrome diagnosisRepair deficiencyFurther studiesA TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer
Wu VT, Kiriazov B, Koch KE, Gu VW, Beck AC, Borcherding N, Li T, Addo P, Wehrspan ZJ, Zhang W, Braun TA, Brown BJ, Band V, Band H, Kulak MV, Weigel RJ. A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer. Molecular Cancer Research 2020, 18: 46-56. PMID: 31619506, PMCID: PMC6942205, DOI: 10.1158/1541-7786.mcr-19-0359.Peer-Reviewed Original ResearchConceptsBreast cancerGene signatureAP-2γHER2-positive breast cancerOutcomes of patientsExpression of estrogenSubset of patientsLuminal breast cancerSubset of HER2AP-2γ transcription factorBreast cancer subtypesPathway analysisPhysiologic effectsClinical relevanceCancer growthHER2Hormone responseCancer subtypesDifferent HER2CancerPatientsRetinoic acid pathwayCancer linesOutcomesCell lines
2019
Su1761 – Prolonged Postoperative Stay After Elective Colorectal Surgery is Associated with Iv Fluid Volume, Older Patient, and Prolonged Open Operation
Koch K, Hart A, Kahl A, Charlton M, Kapadia M, Hrabe J, Hassan I, Cromwell J, Gribovskaja-Rupp I. Su1761 – Prolonged Postoperative Stay After Elective Colorectal Surgery is Associated with Iv Fluid Volume, Older Patient, and Prolonged Open Operation. Gastroenterology 2019, 156: s-1450. DOI: 10.1016/s0016-5085(19)40683-5.Peer-Reviewed Original ResearchSu1767 – Male Gender, Ostomy, Infection, and Iv Fluids are Associated with Increased Risk of Post-Operative Ileus in Elective Colorectal Patients
Koch K, Hart A, Kahl A, Charlton M, Kapadia M, Hrabe J, Hassan I, Cromwell J, Gribovskaja-Rupp I. Su1767 – Male Gender, Ostomy, Infection, and Iv Fluids are Associated with Increased Risk of Post-Operative Ileus in Elective Colorectal Patients. Gastroenterology 2019, 156: s-1451. DOI: 10.1016/s0016-5085(19)40689-6.Peer-Reviewed Original Research