2016
Upgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection?
Edmund L, Rotker KL, Lakis NS, Brito JM, Lepe M, Lombardo KA, Renzulli JF, Matoso A. Upgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection? Human Pathology 2016, 59: 87-93. PMID: 27720731, DOI: 10.1016/j.humpath.2016.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCytoreduction Surgical ProceduresDelayed DiagnosisEarly Detection of CancerHumansKallikreinsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPatient SelectionPredictive Value of TestsProstatectomyProstate-Specific AntigenProstatic NeoplasmsTime FactorsWatchful WaitingConceptsGroup 2Group 1Group 3Needle biopsyActive surveillanceProstate-specific antigen (PSA) screeningPathologic stage pT3Radical prostatectomy findingsLow-risk diseaseGleason score 4High-risk diseaseGleason score 8Prostate needle biopsyProstate cancer managementProstatectomy findingsCytoreductive surgeryStage pT3Screening eraMore patientsPatient selectionAntigen screeningScore 8Radical prostatectomyGleason 6Cancer management
2015
Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review
Leone A, Gershman B, Rotker K, Butler C, Fantasia J, Miller A, Afiadata A, Amin A, Zhou A, Jiang Z, Sebo T, Mega A, Schiff S, Pareek G, Golijanin D, Yates J, Karnes RJ, Renzulli J. Atypical small acinar proliferation (ASAP): Is a repeat biopsy necessary ASAP? A multi-institutional review. Prostate Cancer And Prostatic Diseases 2015, 19: 68-71. PMID: 26857145, DOI: 10.1038/pcan.2015.52.Peer-Reviewed Original ResearchConceptsAtypical small acinar proliferationHigh-grade prostate cancerImmediate repeat biopsySmall acinar proliferationMulti-institutional reviewRepeat biopsySubsequent prostate cancerProstate cancerAcinar proliferationInitial diagnosisProstate biopsyRetrospective multi-institutional reviewAbnormal digital rectal examTransrectal ultrasound-guided biopsyPre-biopsy PSAHigh-grade diseaseDigital rectal examUltrasound-guided biopsyUnderwent repeat biopsyMajority of menElevated PSAGleason 7Clinicopathologic featuresRectal examHigher PSA