Deciphering the molecular organization of GET pathway chaperones through native mass spectrometry
Giska F, Mariappan M, Bhattacharyya M, Gupta K. Deciphering the molecular organization of GET pathway chaperones through native mass spectrometry. Biophysical Journal 2022, 121: 1289-1298. PMID: 35189106, PMCID: PMC9034188, DOI: 10.1016/j.bpj.2022.02.026.Peer-Reviewed Original ResearchConceptsNative mass spectrometryMultiprotein complexesOligomeric stateTail-anchored membrane proteinsLarge multiprotein complexesMass spectrometryChaperone complexMolecular modelingProtein complexesMutational perturbationsMembrane proteinsOligomeric organizationDimerization interfaceIndependent proteinsNative MSEndoplasmic reticulumUnstructured domainsConventional structure determinationStructural organizationMolecular organizationMolecular interfaceCyclic architectureProteinStructure determinationCrystal structure