2021
Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease
Srivastava SP, Goodwin JE, Tripathi P, Kanasaki K, Koya D. Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease. International Journal Of Molecular Sciences 2021, 22: 6027. PMID: 34199672, PMCID: PMC8199750, DOI: 10.3390/ijms22116027.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseKidney diseaseLarge-scale RNA sequencingGenome-wide profiling dataLong non-coding RNAsNon-coding RNAsDisease phenotypeTherapeutic targetNoncoding RNAsRNA sequencingPathogenesis of diabetesPotential therapeutic targetCrosstalk mechanismsRegulatory microRNAsCrosstalk interactionsLncRNAsMechanism of actionProfiling dataMicroRNAsAberrant expressionDiverse targetsDisease processDiabetesRNADisease
2020
Metabolic reprogramming by N‐acetyl‐seryl‐aspartyl‐lysyl‐proline protects against diabetic kidney disease
Srivastava SP, Goodwin JE, Kanasaki K, Koya D. Metabolic reprogramming by N‐acetyl‐seryl‐aspartyl‐lysyl‐proline protects against diabetic kidney disease. British Journal Of Pharmacology 2020, 177: 3691-3711. PMID: 32352559, PMCID: PMC7393199, DOI: 10.1111/bph.15087.Peer-Reviewed Original ResearchConceptsACE inhibitorsDiabetic kidneyKidney fibrosisEffects of ACEIsEnd-stage renal diseaseDiabetic CD-1 miceKidney cell metabolismAbnormal glucose metabolismDiabetic kidney diseaseFirst-line drugsCD-1 miceMesenchymal transformationFatty acid oxidationMitochondrial fatty acid oxidationAntifibrotic mediatorsFatty acid metabolismDiabetic patientsRenal diseaseAntifibrotic mechanismsSevere fibrosisACE inhibitionKidney diseaseAntifibrotic actionReceptor antagonistC57BL6 mice
2018
SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis
Srivastava SP, Li J, Kitada M, Fujita H, Yamada Y, Goodwin JE, Kanasaki K, Koya D. SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis. Cell Death & Disease 2018, 9: 997. PMID: 30250024, PMCID: PMC6155322, DOI: 10.1038/s41419-018-1057-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarnitine O-PalmitoyltransferaseCell LineDiabetes Mellitus, ExperimentalDiabetic NephropathiesFibrosisGene Knockdown TechniquesGlucoseGlycolysisHumansHypoxia-Inducible Factor 1, alpha SubunitKidneyMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPyruvate KinaseSirtuin 3StreptozocinTransfectionTransforming Growth Factor beta2ConceptsDiabetic kidneyAbnormal glycolysisAberrant glycolysisSIRT3 suppressionMouse modelProgressive diabetic kidney diseaseDiabetic kidney diseaseDiabetic mouse modelAberrant glucose metabolismSIRT3 protein levelsSIRT3 siRNADiabetic miceKidney diseaseKidney fibrosisSystemic administrationFibrogenic pathwaysSIRT3 deficiencyGlucose metabolismTherapeutic targetFibrosisSIRT3 levelsHIF1α accumulationFibrogenic phenotypeKidneyGrowth factor
2015
Glucocorticoids and the Cardiovascular System
Goodwin JE. Glucocorticoids and the Cardiovascular System. Advances In Experimental Medicine And Biology 2015, 872: 299-314. PMID: 26216000, DOI: 10.1007/978-1-4939-2895-8_13.Peer-Reviewed Original Research
2013
A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia
Goodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. Clinical Nephrology 2013, 82: 205-210. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/cn107767.Peer-Reviewed Original ResearchConceptsStem cell transplantHematopoietic stem cell transplantCell transplantRenal insufficiencyKidney biopsyPediatric patientsNephrotic syndromeExtensive foot process effacementAbnormal lymphocyte responsesT-cell acute lymphoblastic leukemiaChronic kidney diseaseChronic interstitial nephritisAcute lymphoblastic leukemiaPre-conditioning regimensFoot process effacementHost diseaseImmunosuppressive therapyRenal failureInterstitial nephritisLymphocyte responsesCommon sequelaeInterstitial infiltratesProphylactic medicationKidney diseaseLikely multifactorial
2011
Glucocorticoid-induced hypertension
Goodwin JE, Geller DS. Glucocorticoid-induced hypertension. Pediatric Nephrology 2011, 27: 1059-1066. PMID: 21744056, DOI: 10.1007/s00467-011-1928-4.BooksConceptsGlucocorticoid-induced hypertensionForms of hypertensionGlucocorticoid receptorRenal mineralocorticoid receptorsCommon clinical problemVascular smooth muscleBlood pressure regulationVascular endothelial cellsTissue-specific contributionsMineralocorticoid receptorTreatment strategiesClinical dataHypertensionSmooth muscleClinical problemAnimal modelsKidney tissuePressure regulationOrgan systemsWater reabsorptionEndothelial cellsExtra-vascular tissuesReceptorsPathogenesisMouse genetics