2011
Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism
Lai G, Schneider HD, Schwarzenberger JC, Hirsch J. Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism. Radiology 2011, 260: 521-30. PMID: 21628495, DOI: 10.1148/radiol.11101576.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusControl subjectsSpeech stimulationFunctional MR imagingFunctional MR imaging activationFunctional magnetic resonanceAutistic subjectsMR imagingPrimary auditory cortexWilcoxon rank sum testInstitutional review boardMagnetic resonanceSpread of activityTwo-sample t-testRank sum testUnivariate general linear model analysisProspective studyMR evaluationAuditory cortexGeneral linear model analysisControl groupObjective indicatorsTemporal gyrusInformed consentReview board
2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Mitsumoto H, Ulu A, Pullman S, Gooch C, Chan S, Tang M, Mao X, Hays A, Floyd A, Battista V, Montes J, Hayes S, Dashnaw S, Kaufmann P, Gordon P, Hirsch J, Levin B, Rowland L, Shungu D. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007, 68: 1402-1410. PMID: 17452585, DOI: 10.1212/01.wnl.0000260065.57832.87.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAspartic AcidBiomarkersCreatineDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMotor CortexMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalNeural ConductionProspective StudiesTranscranial Magnetic StimulationConceptsMotor unit number estimationCentral motor conduction timeMotor conduction timeAcetyl-aspartate concentrationsUMN syndromeControl subjectsTibialis anteriorConduction timeObjective markersLower motor neuron dysfunctionLower motor neuron involvementALS Functional RatingMotor neuron involvementMotor neuron dysfunctionProton MR spectroscopic imagingTranscranial magnetic stimulationRatio of NAADiffusion tensor imagingLMN syndromesDisease activityNeuron involvementNeuron dysfunctionMR spectroscopic imagingFunctional ratingObjective biomarkers