2013
Learning not to Fear: Neural Correlates of Learned Safety
Kong E, Monje FJ, Hirsch J, Pollak DD. Learning not to Fear: Neural Correlates of Learned Safety. Neuropsychopharmacology 2013, 39: 515-527. PMID: 23963118, PMCID: PMC3895233, DOI: 10.1038/npp.2013.191.Peer-Reviewed Original ResearchConceptsSpecific affective disordersNeural correlatesAffective disordersFear responsesNeural mechanismsNeurobiological underpinningsInstances of protectionNeural circuitryTranslational neuroscienceChronic stressBasis of insightsNeuroscienceDisordersAnxietyFearIdentification of episodesUnderpinningsCorrelatesCircuitryPeopleAbilitySymptomsHumans
2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulate
2010
A translational bridge between mouse and human models of learned safety
Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Annals Of Medicine 2010, 42: 127-134. PMID: 20121549, DOI: 10.3109/07853890903583666.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexNeural circuitryPrefrontal cortexAnimal experimentsTranslational bridgeFunctional magnetic resonanceParallel groupSafety signalsPupillary constrictionNoxious stimuliUnderlying neural circuitryHuman studiesExperimental animalsHuman modelNeural connectionsAnimal protocolsMiceCaudate responseNeutral stimuliNeural responsesNeural substratesDiffusion tensorAmygdalaCortexMolecular mechanisms
2009
Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze
Schneier FR, Kent JM, Star A, Hirsch J. Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze. Psychiatry Research 2009, 173: 248-250. PMID: 19628377, PMCID: PMC2745296, DOI: 10.1016/j.pscychresns.2008.06.004.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderEye gazeAnxiety disordersPathophysiology of SADSubmissive behaviorFunctional magnetic resonance imagingDirect eye gazeAverted gazeDirect gazeNeural responsesPrefrontal cortexSAD subjectsAnterior cingulateNeural circuitryNeural activityBrain regionsGazeMagnetic resonance imagingHealthy volunteersResonance imagingDisordersInsulaCingulateFearSignificant differences