2024
Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indices
2022
Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon
Villasis E, Castillo S, Guzman M, Torres J, Gomez J, Garro K, Cordova AM, Reategui C, Abanto C, Vinetz J, Gamboa D, Torres K. Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon. Frontiers In Cellular And Infection Microbiology 2022, 12: 901423. PMID: 36118037, PMCID: PMC9471197, DOI: 10.3389/fcimb.2022.901423.Peer-Reviewed Original ResearchConceptsCase-control studyAntimalarial treatmentMalaria symptomsHematological parametersControl individualsCommon malaria symptomsNegative microscopy resultsHistory of comorbiditiesMalaria control measuresClinical immunityMalaria microscopyAsymptomatic infectionMalaria infectionEpidemiological characteristicsChronic infectionMost infectionsMalaria eliminationDay 21Positive qPCR resultsInfected individualsPopulation screeningSYM groupInfectionQPCR resultsLast month
2021
Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context
2018
Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination
Martin TCS, Vinetz JM. Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination. Malaria Journal 2018, 17: 89. PMID: 29466991, PMCID: PMC5822557, DOI: 10.1186/s12936-018-2243-3.Peer-Reviewed Original ResearchConceptsTransmission-blocking vaccinesPlasmodium vivax parasitaemiaLow transmission settingsControl of transmissionVivax parasitaemiaChloroquine resistanceAsymptomatic carriageMalaria eliminationNew therapiesPlasmodium vivaxImportant causeCarrier stateImmunological interactionsVaccineOnward infectionInfectionParasite transmissionEradication effortsMosquitoesMorbidityParasitaemiaTherapyMortalityDiagnosisVivax
2016
Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax