2020
E2F8 Induces Cell Proliferation and Invasion through the Epithelial–Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer
Eoh KJ, Kim HJ, Lee JW, Kim LK, Park SA, Kim HS, Kim YT, Koo PJ. E2F8 Induces Cell Proliferation and Invasion through the Epithelial–Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer. International Journal Of Molecular Sciences 2020, 21: 5813. PMID: 32823614, PMCID: PMC7460858, DOI: 10.3390/ijms21165813.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Knockdown TechniquesHumansMice, NudeMultivariate AnalysisNeoplasm InvasivenessOvarian NeoplasmsPrognosisProgression-Free SurvivalReceptors, NotchRepressor ProteinsSignal TransductionTumor BurdenXenograft Model Antitumor AssaysConceptsOvarian cancer cell linesProgression-free survivalOvarian cancer patientsOvarian cancerCancer cell linesCancer patientsCell proliferationCell linesKnockdown inhibited cell proliferationOvarian cancer tissuesNormal ovarian tissuesReduced tumor sizeOvarian cancer progressionPathway-related markersXenograft mouse modelEpithelial-mesenchymal transitionInhibited cell proliferationNotch Signaling PathwayBio-functional effectsOvarian malignancyInduces cell proliferationTumor sizePrognostic markerClinical dataMouse model
2017
Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma.
Parameswaran J, Lee J, Sandoval-Schaefer T, Koo J, Burtness B. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2017, 35: e14105-e14105. DOI: 10.1200/jco.2017.35.15_suppl.e14105.Peer-Reviewed Original ResearchAurora kinase APhospho-histone H3Mitotic entryCell deathHNSCC cell linesMechanism of synergyDefective spindle assemblyConfocal microscopyAURKA inhibitorsCell linesChromatin organizationAURKA inhibitor MLN8237P-CDK1Spindle assemblyKinase AMitotic catastropheWestern blot analysisTumor growthFormation assaysAURKA expressionHPV-negative HNSCC cell linesCell viability assaysMouse xenograft modelPotential therapeutic targetAURKA inhibition