2012
Capturing the Angel in “Angel Dust”: Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans
Moghaddam B, Krystal JH. Capturing the Angel in “Angel Dust”: Twenty Years of Translational Neuroscience Studies of NMDA Receptor Antagonists in Animals and Humans. Schizophrenia Bulletin 2012, 38: 942-949. PMID: 22899397, PMCID: PMC3446228, DOI: 10.1093/schbul/sbs075.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric RegulationAnimalsAntipsychotic AgentsBrief Psychiatric Rating ScaleCerebral CortexDisease Models, AnimalDopamineEmotionsGlutamic AcidHumansKetamineNeurosciencesPhencyclidinePsychoses, Substance-InducedReceptor, Metabotropic Glutamate 5Receptors, Dopamine D2Receptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateSchizophreniaSynapsesTranslational Research, BiomedicalConceptsNMDA receptor antagonistReceptor antagonistDopamine hypothesisN-methyl-D-aspartate receptor antagonistGlutamate synaptic functionTranslational neuroscience studiesTreatment of schizophreniaPathophysiology of schizophreniaPotential treatment targetPotential new targetsDopamine antagonistsCortical functionAnimal studiesTreatment targetsClinical testingSynaptic functionAntagonistTranslational toolSchizophreniaTranslational research fundingTranslational researchPotential mechanismsNew targetsAngel dustSystems neuroscience
2000
Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies
Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNeurobiology of depressionGABAergic functionTechnique of PETCSF GABA concentrationsGABA-mimetic agentsNovel neuroimaging techniquesNondepressed comparison subjectsMood stabilizingChronic administrationGABAergic transmissionGABAergic neurotransmissionAntidepressant propertiesGABAergic abnormalitiesDepressed patientsAntidepressant drugsDisorder pathophysiologyLower plasmaComparison subjectsAnimal studiesGABAergic contributionGABA concentrationNovel imaging techniqueNeuroimaging studiesNeuroimaging techniquesDepression
1988
Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse
Kosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. Recent Developments In Alcoholism 1988, 6: 49-68. PMID: 3283864, DOI: 10.1007/978-1-4615-7718-8_3.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSubstance abuseHuman studiesEndogenous opioid systemCentral catecholaminesOpioid systemBrain catecholaminesEmotional response modelsTherapeutic approachesAnimal studiesSignificant biological contributionStress disorderNonhuman primatesBehavioral correlatesCatecholaminesRelevant animalBiological mechanismsRecent studiesAbuseIndirect measureSyndromeIncidenceStudy
1983
A preliminary description of acute physical dependence on morphine in the vervet monkey
Krystal JH, Redmond DE. A preliminary description of acute physical dependence on morphine in the vervet monkey. Pharmacology Biochemistry And Behavior 1983, 18: 289-291. PMID: 6682230, DOI: 10.1016/0091-3057(83)90379-9.Peer-Reviewed Original ResearchConceptsAcute physical dependencePhysical dependencePrevious animal studiesDevelopment of dependenceIntravenous morphineOpioid withdrawalOpiate dependencyNaloxone administrationNonhuman primate subjectsSyndrome characteristicsAnimal studiesMorphinePrimate subjectsVervet monkeysHoursMonkeysOpioidsPrimate speciesAdministration