1999
Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits
Jentsch J, Taylor J, Elsworth J, Redmond D, Roth R. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999, 90: 823-832. PMID: 10218783, DOI: 10.1016/s0306-4522(98)00481-3.Peer-Reviewed Original ResearchConceptsCognitive deficitsSubchronic phencyclidine administrationDorsolateral prefrontal cortexFrontal cortexCortical dopamine transmissionReduced dopaminergic functionFrontostriatal functionDetour taskCognitive performanceDopamine utilizationPhencyclidine exposurePrefrontal cortexPerformance impairmentPrelimbic cortexBrain regionsCognitive dysfunctionCortical impairmentCortical regionsCognitive impairmentDopaminergic functionPhencyclidine administrationDopamine transmissionSpecific subregionsCortexPsychotomimetic drug phencyclidine
1997
Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine
Jentsch J, Redmond D, Elsworth J, Taylor J, Youngren K, Roth R. Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine. Science 1997, 277: 953-955. PMID: 9252326, DOI: 10.1126/science.277.5328.953.Peer-Reviewed Original ResearchConceptsDopamine utilizationPrefrontal cortexAtypical antipsychotic drug clozapineLong-term administrationDirect drug effectAntipsychotic drug clozapinePsychotomimetic drug phencyclidineAdministration of phencyclidineDorsolateral prefrontal cortexDopamine hypofunctionPrefrontal cortex functionCognitive dysfunctionPhencyclidine treatmentBehavioral deficitsDopamine dysfunctionPsychiatric disordersDrug effectsDrug clozapineDrug phencyclidineBrain regionsCognitive deficitsCortex functionCognitive functionPhencyclidineCortexDown-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.
Lidow M, Elsworth J, Goldman-Rakic P. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. Journal Of Pharmacology And Experimental Therapeutics 1997, 281: 597-603. PMID: 9103549.Peer-Reviewed Original ResearchConceptsChronic treatmentAntipsychotic drugsPrefrontal cortexReceptor antagonismDopamine receptorsD5 dopamine receptor mRNAD2 dopamine receptor antagonismD2 receptor antagonismDopamine receptor mRNAVehicle control groupTreatment of schizophreniaD1 classD5 dopamine receptorsDopamine receptor antagonismPrimate prefrontal cortexD5 mRNAsDopaminergic receptorsAntipsychotic medicationAntipsychotic efficacyD2 antagonistTherapeutic rangeAntipsychotic activityPharmacological spectrumReceptor mRNARibonuclease protection assays
1990
COGNITIVE AND MOTOR DEFICITS IN THE ACQUISITION OF AN OBJECT RETRIEVAL/DETOUR TASK IN MPTP-TREATED MONKEYS
TAYLOR J, ELSWORTH J, ROTH R, SLADEK J, REDMOND D. COGNITIVE AND MOTOR DEFICITS IN THE ACQUISITION OF AN OBJECT RETRIEVAL/DETOUR TASK IN MPTP-TREATED MONKEYS. Brain 1990, 113: 617-637. PMID: 2364263, DOI: 10.1093/brain/113.3.617.Peer-Reviewed Original Research