2005
Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures
Bjugstad K, Redmond D, Teng Y, Elsworth J, Roth R, Blanchard B, Snyder E, Sladek J. Neural Stem Cells Implanted into MPTP-Treated Monkeys Increase the Size of Endogenous Tyrosine Hydroxylase-Positive Cells Found in the Striatum: A Return to Control Measures. Cell Transplantation 2005, 14: 183-192. PMID: 15929553, DOI: 10.3727/000000005783983098.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Tissue TransplantationCell SizeChlorocebus aethiopsHumansMaleMPTP PoisoningNeostriatumNeuronsStem Cell TransplantationTransplantation, HeterologousTyrosine 3-MonooxygenaseConceptsTyrosine hydroxylase-positive cellsNeural stem cellsHydroxylase-positive cellsSubstantia nigraHuman neural stem cellsParkinson's diseaseHuman NSCsCaudate nucleusEffects of NSCsPresence of NSCsImplanted neural stem cellsRight substantia nigraUntreated control monkeysRight caudate nucleusCell populationsAfrican green monkeysEndogenous cell populationsStem cellsMPTP damageMPTP treatmentStriatal environmentNigrostriatal pathwayDopamine neuronsControl monkeysSelective dopaminergic
1998
Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study
Elsworth J, Brittan M, Taylor J, Sladek J, Redmond D, Innis R, Zea-Ponce Y, Roth R. Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: an autoradiographic study. Brain Research 1998, 795: 55-62. PMID: 9622593, DOI: 10.1016/s0006-8993(98)00252-2.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBenzofuransBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDisease Models, AnimalDopamine AgentsFetal Tissue TransplantationImage Processing, Computer-AssistedIodine RadioisotopesMesencephalonParkinson Disease, SecondaryRadioligand AssayReceptors, Dopamine D2Up-RegulationConceptsFetal ventral mesencephalonD2 receptor bindingVentral mesencephalonDorsal striatumAutoradiographic studyDopamine uptake site densityPostsynaptic dopamine receptor activationVentral striatumDopamine concentrationsStriatal D2 receptor bindingReceptor bindingD2 receptor upregulationPostsynaptic dopamine transmissionTetrahydropyridine-treated monkeysStriatal D2 receptorsDopamine receptor activationPrevious autoradiographic studiesAfrican green monkeysDonor neuronsIntrastriatal graftingParkinsonian primatesNeural transplantationReceptor upregulationStriatal circuitryMotor functionIntrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. DOI: 10.1016/s0963-6897(98)00007-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Tissue TransplantationCell CountCell SurvivalChlorocebus aethiopsDopamineFetal Tissue TransplantationGraft RejectionGraft SurvivalHumansNeuronsTissue DonorsConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extentIntrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. PMID: 9588591, DOI: 10.1177/096368979800700204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Tissue TransplantationCell CountCell SurvivalChlorocebus aethiopsDopamineFetal Tissue TransplantationGraft RejectionGraft SurvivalHumansNeuronsTissue DonorsConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extent
1997
Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry. Cell Transplantation 1997, 6: 135-140. DOI: 10.1016/s0963-6897(97)00003-1.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainBrain metabolismEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activityNonhuman primatesMetabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry. Cell Transplantation 1997, 6: 135-140. PMID: 9142445, DOI: 10.1177/096368979700600207.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsBrain energy metabolismCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismEnergy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activity
1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regionsRestoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1016/0963-6897(95)02034-9.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatumRestoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1177/096368979600500220.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatum
1995
General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease
Sass K, Buchanan C, Westerveld M, Marek K, Farhi A, Robbins R, Naftolin F, Vollmer T, Leranth C, Roth R, Price L, Bunney B, Elsworth J, Hoffer P, Redmond D, Spencer D. General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease. JAMA Neurology 1995, 52: 680-686. PMID: 7619024, DOI: 10.1001/archneur.1995.00540310050016.Peer-Reviewed Original ResearchConceptsCognitive abilitiesNonverbal cognitive abilityVerbal cognitive abilityInformation-processing speedVerbal memoryNeuropsychological profileTest batteryCognitive functionNormal cognitive functionCognitive dysfunctionRight caudate nucleusCaudate nucleusFactor analysisTissue transplantationParkinson's diseaseSham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys. Cell Transplantation 1995, 4: 13-26. DOI: 10.1016/0963-6897(94)00035-i.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effectsSham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys. Cell Transplantation 1995, 4: 13-26. PMID: 7728327, DOI: 10.1177/096368979500400105.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effects
1994
Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function
Elsworth J, Al-Tikriti M, Sladek J, Taylor J, Innis R, Redmond D, Roth R. Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function. Experimental Neurology 1994, 126: 299-304. PMID: 7925828, DOI: 10.1006/exnr.1994.1068.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsParkinson Disease, SecondaryRadioligand AssaySerotonin Plasma Membrane Transport ProteinsSubstantia NigraTransplantation, HeterotopicTransplantation, HomologousConceptsCaudate nucleusFetal ventral mesencephalic cellsIntrastriatal nigral graftsVentral mesencephalic cellsAdult MPTPNigral graftsSerotonergic fibersTransplantation procedureMesencephalic cellsNovel radioligandNeurochemical identityDopamine transporterTransporter sitesSerotonin transporterBehavioral functionsMPTPCocaine analogMonkeysCocaine derivativePreliminary studyHigh affinityDopaminergicGraft
1993
Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates?
Sladek J, Collier T, Elsworth J, Taylor J, Roth R, Redmond D. Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates? Experimental Neurology 1993, 124: 134-139. PMID: 8282070, DOI: 10.1006/exnr.1993.1184.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrain Tissue TransplantationCorpus StriatumDopamineFetal Tissue TransplantationHumansMacaca mulattaMesencephalonNerve RegenerationNeuritesNeuronsSubstantia NigraNeural Transplantation for Neurodegenerative Diseases: Past, Present, and Futurea
REDMOND D, ROTH R, SPENCER D, NAFTOLIN F, LERANTH C, ROBBINS R, MAREK K, ELSWORTH J, SASS K, TAYLOR J, SLADEK J. Neural Transplantation for Neurodegenerative Diseases: Past, Present, and Futurea. Annals Of The New York Academy Of Sciences 1993, 695: 258-266. PMID: 8239293, DOI: 10.1111/j.1749-6632.1993.tb23064.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Tissue TransplantationFetal Tissue TransplantationHumansParkinson DiseaseParkinson Disease, SecondaryConceptsNeural transplantationParkinson's diseaseDopamine neuronsCellular replacementClinical treatmentFetal cellsNeural tissue transplantsNeural tissueIdiopathic Parkinson's diseaseDopamine-producing cellsFunctional effectsBest medical treatmentFetal neural tissueImportant functional effectsHuman neural tissueEssential neuromodulatorDrug therapyIdiopathic diseaseClinical conditionsTherapeutic experimentsBrain cellsIneffective treatmentMedical treatmentTissue transplantsTransplantationFetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates
Sladek J, Elsworth J, Roth R, Evans L, Collier T, Cooper S, Taylor J, Redmond D. Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates. Experimental Neurology 1993, 122: 16-27. PMID: 8101820, DOI: 10.1006/exnr.1993.1103.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusMesencephalic dopamine cell groupsTyrosine hydroxylase-positive neuronsTissue dopamine levelsUnfixed brain slicesDopamine cell groupsCell survivalDopamine cell survivalDopamine cell numberDays of gestationEarly gestation tissuesTime of implantationAfrican green monkeysVideo-based imagingGraft survivalMesencephalic tissueDonor graftsGestational ageNeural graftsNeurological disabilityDopaminergic neuronsGraft sizeDopamine contentSingle graft
1991
Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls
Taylor J, Elsworth J, Roth R, Sladek J, Collier T, Redmond D. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Experimental Brain Research 1991, 85: 335-348. PMID: 1893983, DOI: 10.1007/bf00229411.Peer-Reviewed Original ResearchConceptsCaudate nucleusBehavioral deficitsHealthy behaviorsFetal substantia nigra cellsFetal substantia nigraIdiopathic Parkinson's diseasePoverty of movementType of graftDays/weekSubstantia nigra cellsTime of sacrificePre-treatment levelsSN cellsSpecific behavioral effectsMPTP treatmentMPTP toxicityParkinsonian signsSubstantia nigraControl subjectsInitiation of movementBrain sitesLimb tremorParkinson's diseaseControl animalsMPTP
1990
Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys
Taylor J, Elsworth J, Roth R, Collier T, Sladek J, Redmond D. Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. Progress In Brain Research 1990, 82: 543-559. PMID: 2290957, DOI: 10.1016/s0079-6123(08)62645-x.Peer-Reviewed Original ResearchConceptsCSF HVA levelsHVA levelsBehavioral recoveryCaudate nucleusSN graftsDopamine neuronsDopamine productionHVA/dopamine ratioCentral dopamine productionFetal substantia nigraStriatum of subjectsSubstantia nigra transplantsRelease of dopamineImproved parkinsonismHost striatumHost brainFetal graftsMPTP administrationParkinsonian signsTH immunohistochemistrySubstantia nigraDopamine ratioSmall graftsBehavioral deficitsGraft