2000
TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat
Morrow B, Roth R, Elsworth J. TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat. Brain Research Bulletin 2000, 52: 519-523. PMID: 10974491, DOI: 10.1016/s0361-9230(00)00290-2.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexPrefrontal cortexExploratory behaviorSample taskFamiliar objectsNovel objectsMesoprefrontal dopamine neuronsTrimethylthiazolineMemoryPsychological stressTMT exposureObject recognition methodPredator odorSet of objectsCortexElevated serum corticosteroneDopaminergic inputDopaminergic activityBrief exposureDopaminergic innervationSerum corticosteroneDopamine neuronsDopamine metabolismObjectsRecognition method
1997
(S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization.
Morrow B, Lee E, Taylor J, Elsworth J, Nye H, Roth R. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 712-21. PMID: 9353390.Peer-Reviewed Original ResearchConceptsHA-966Dopamine metabolismMedial prefrontal cortexCocaine sensitizationNucleus accumbensHigh doseAcute cocaine-induced locomotionPrefrontal cortexGABAB receptor bindingCocaine-induced locomotionGamma-aminobutyric acidStress-induced increaseFear-inducing behaviorDopamine utilizationGABAB receptorsRestraint stressControl ratsLocomotor sensitizationDopaminergic neurotransmissionShell subdivisionBaclofen bindingCortical membranesPositive enantiomerWeight gainReceptor binding
1985
Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand.
Sandler M, Glover V, Clow A, Elsworth J. Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand. Progress In Clinical And Biological Research 1985, 192: 359-62. PMID: 3001762.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyHumansIsatinMonoamine Oxidase InhibitorsPanicReceptors, GABA-AStress, PsychologicalConceptsLactate-induced panic attacksBenzodiazepine receptor bindingBenzodiazepine receptor ligandsBenzodiazepine withdrawalBenzodiazepine receptorsLow molecular weight inhibitorsPanic attacksTribulin outputAnxiety disordersReceptor bindingMonoamine oxidaseReceptor ligandsAnimal brainsWeight inhibitorsHuman plasmaInhibitorsHuman urineTribulinMonoaminesBrainReceptorsUrine