John Elefteriades, MD
William W.L. Glenn Professor of Surgery (Cardiac)Cards
About
Research
Overview
Dr. Elefteriades and his team at the Aortic Institute have contributed to our understanding of when (at what size) aneurysms are likely to rupture and when surgery is necessary. They have elucidated the family patterns of aneurysm disease, as well as determined the exact changes in "letters" of the genetic alphabet that allow aneurysms to develop. They have developed and advanced the techniques for safe, effective surgery on the thoracic aorta.
Medical Research Interests
Academic Achievements & Community Involvement
Clinical Care
Overview
John Elefteriades, MD, is one of the leading heart surgeons in the United States. He has performed all types of adult cardiac surgeries, including coronary artery bypass grafting and artificial heart implantation. He is founding director (Emeritus) of the Aortic Institute at Yale New Haven Hospital.
Dr. Elefteriades is a pioneer in the use of extreme cooling, or hypothermia, to allow surgeons to stop a patient's heart long enough to carry out cardiac surgery. Once the procedure is complete, the patient is warmed and the heart restarted.
He is a strong advocate of general screening to discover if people have aortic aneurysms, or bulges in the main artery connected to the heart. Left untreated, aortic aneurysms can lead to ruptures that cause death. “With aneurysm disease, the first symptom is death. Most people feel no pain. So, it would be a great advance to have a general screening test,” Dr. Elefteriades says.
At the Aortic Institute, one of the nation's largest facilities for treatment and study of the aorta, Dr. Elefteriades’ team has developed an “RNA Signature” blood test to detect aneurysm disease. This work is a step along the path to developing a general screening technique that’s affordable and accurate enough for widespread use.
Working with other researchers at Yale, he also has assembled a database of aneurysm disease cases, which enables the researchers to find patterns in patient populations. They already have discovered links between weightlifting and aneurysms. They also gathered evidence that allows physicians to decide when (that is, at what aneurysm size) it is necessary to perform surgery in order to prevent a cataclysmic event in patients with an aneurysm.
In addition to his work with aneurysms, Dr. Elefteriades is the author of a medical mystery/ethics fiction thriller called “Transplant,” which was a finalist in the Next Generation Indie Book Awards as a best first novel. He also published a collection of inspirational patient stories entitled “Extraordinary Hearts: A Journey of Cardiac Medicine and the Human Spirit.” As well, he has published many medical textbooks and over 500 scientific articles and chapters. He has lectured and/or operated in 33 countries.
Dr. Elefteriades has been named among the Best Doctors in America consistently for two decades. He is a professor of cardiothoracic surgery at Yale School of Medicine. In 2018, Dr. Elefteriades was granted an Honorary PhD by the University of Liege (Belgium) for his contributions to scientific understanding and clinical care of thoracic aortic aneurysms. In 2020, he was named by expertscape as the leading aneurysm expert in the world.
Clinical Specialties
Fact Sheets
Aortic Aneurysm
Learn More on Yale MedicineAVNeo (Aortic valve neocuspidization, Ozaki Procedure)
Learn More on Yale MedicineHeart Valve Replacement
Learn More on Yale MedicineMitral Valve Surgery
Learn More on Yale Medicine
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- AB of Thoracic Surgery
- Latest Certification Date
- 2014
- Original Certification Date
- 1985
Yale Medicine News
News & Links
Media
- This image from our Scientific American article conveys vividly the threat represented by aneurysms of the ascending aorta, which are silent until they tear or rupture. If you have a family history of such aneurysms, you should be investigated.
- If you can cross your thumb all the way over the edge of your flat palm, it is possible that you have aneurysm disease. This Thumb-Palm Sign is evidence that the long bones are excessive and the joints are lax.. This should be called to the attention of your doctor. An ECHO or CT scan of your thoracic aorta will probably be needed.
News
- August 12, 2024
AI Accurately Diagnoses a Genetic Condition From Facial Photographs
- January 02, 2024Source: Medscape
Ascending Thoracic Aortic Aneurysms: A 'Silver Lining'?
- August 17, 2022
AHA Scientific Sessions 2022: Latest updates from Yale Cardiovascular Medicine
- May 25, 2021Source: YaleNews
All in Favor of a Test for Aortic Aneurysms, Raise Your Hand