A polymorphism of the β1-adrenergic receptor is associated with low extraversion
Stein MB, Schork NJ, Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with low extraversion. Biological Psychiatry 2004, 56: 217-224. PMID: 15312808, DOI: 10.1016/j.biopsych.2004.05.020.Peer-Reviewed Original ResearchAdolescentAdultArginineChi-Square DistributionCluster AnalysisEthnicityExtraversion, PsychologicalFemaleGene FrequencyGlycineHumansMalePersonality InventoryPhenotypePolymorphism, GeneticPsychiatric Status Rating ScalesReceptors, Adrenergic, beta-1Regression AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSerineSex CharacteristicsSurveys and QuestionnairesNOTCH4 gene haplotype is associated with schizophrenia in African Americans
Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry 2004, 55: 112-117. PMID: 14732589, DOI: 10.1016/s0006-3223(03)00588-2.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanChi-Square DistributionCysteineDiagnostic and Statistical Manual of Mental DisordersFemaleGene FrequencyGenotypeGlycineHaplotypesHumansLinkage DisequilibriumMalePolymerase Chain ReactionPolymorphism, Single NucleotideProto-Oncogene ProteinsReceptor, Notch4Receptors, Cell SurfaceReceptors, NotchSchizophreniaThreonineConceptsHealthy control subjectsControl subjectsSingle nucleotide polymorphismsExact testSchizophrenia patientsAfrican AmericansFisher's exact testNOTCH4 locusChi-square testComparison of alleleEuropean-American subjectsPositive linkage disequilibriumAA subjectsPatientsSchizophreniaSpecific markersHaplotype frequenciesT associatesLinkage disequilibriumEA subjectsNOTCH4 geneSubjectsGene haplotypesAmerican subjectsNucleotide polymorphisms