2011
Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates
Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. Psychiatry Research 2011, 192: 37-44. PMID: 21377844, PMCID: PMC4090111, DOI: 10.1016/j.pscychresns.2010.11.006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnxietyBehavior, AnimalBrain MappingCorpus CallosumCross-Sectional StudiesFearGene FrequencyGenotypeHippocampusImage Processing, Computer-AssistedLinear ModelsMacaca radiataMagnetic Resonance ImagingMaleSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalConceptsBrain developmentNonhuman primatesCorpus callosum measurementsMale bonnet monkeysMiddle temporal gyrus volumeCorpus callosum developmentMale nonhuman primatesEarly life stressReduced hippocampusCorpus callosumMRI measuresBonnet monkeysPsychiatric disordersMRI scansHippocampal volumetricsSerotonin transporter genotypeCC sizeStress paradigmHippocampusStress reactivityMorphometry assessmentBehavioral assessmentTransporter genotypeAnxious behaviorEarly stress
2004
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.Peer-Reviewed Original ResearchConceptsSocial supportDevelopment of depressionGene promoter polymorphismTransporter gene promoter polymorphismSerotonin transporter gene promoter polymorphismHigher depression ratingsDepression ratingsClinical dataModerate depressionPsychiatric disordersDepression scoresPromoter polymorphismNegative sequelaeModerate riskDepressionEarly stressChildrenS genotypeHistory of maltreatmentRiskShort allele