2021
Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder
Wright M, De Aquino J, Bystrak T. Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder. Substance Use & Addiction Journal 2021, 42: 493-496. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.Peer-Reviewed Original ResearchMeSH KeywordsDelayed-Action PreparationsHumansInjections, IntramuscularNaltrexoneNarcotic AntagonistsOpioid-Related DisordersUnited StatesConceptsHigh-risk patientsOpioid use disorderUse disorderReducing opioid cravingDosing strategiesFrequent dosingTreatment of opioid use disorderOpioid overdoseNovel dosing strategiesAlternative dosing strategiesCraving suppressionIncreased cravingEvidence of side effectsOpioid cravingShort-term safetyNaltrexone administrationIncreased dosing frequencyOpioid abstinenceNational opioid crisisRisk of opioid overdoseNaltrexoneExtended-releaseRisk patientsHigh-potencyPatient doseThe Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder
De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansNarcotic AntagonistsOpioid-Related DisordersReceptors, Opioid, muSubstance Withdrawal SyndromeConceptsUnique pharmacological profileOpioid use disorderOpioid withdrawalPotential dose-dependent effectsPlacebo-controlled clinical trialLong-term treatment outcomesFull opioid agonistsStandard induction regimensOpen-label studyFirst-line pharmacotherapySchedule of administrationMu-opioid receptorsAvailability of buprenorphineDose-dependent effectFuture translational researchInduction regimensOpioid taperOpioid toneFirst doseClinical outcomesClinical evidenceOpioid agonistsBuprenorphine formulationsDaily dosesClinical trials
2020
Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting.
De Aquino J, Fairgrieve C, Klaire S, Garcia-Vassallo G. Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting. Journal Of Addiction Medicine 2020, 14: e271-e273. PMID: 32011408, PMCID: PMC7392785, DOI: 10.1097/adm.0000000000000618.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineHumansMethadoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersOutpatientsVeteransConceptsOpioid use disorderPrecipitated withdrawalTreatment of opioid use disorderCessation of methadoneMicro-dose protocolRisk of precipitated withdrawalMethadone to buprenorphineOpioid agonist therapyTransition to buprenorphineAgonist therapyOpioid useOutpatient protocolUse disorderOutpatient settingVeterans Affairs settingsBuprenorphineMethadonePsychiatry settingWithdrawalTransition protocolDemonstrating feasibilityInductionOpioidTherapyPatients