2024
The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPain
2021
Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder
Wright M, De Aquino J, Bystrak T. Case Report: Increasing the Frequency of Intramuscular Naltrexone Administration in a High Risk Patient with Opioid use Disorder. Substance Use & Addiction Journal 2021, 42: 493-496. PMID: 33689592, DOI: 10.1080/08897077.2021.1876811.Peer-Reviewed Original ResearchConceptsHigh-risk patientsOpioid use disorderUse disorderReducing opioid cravingDosing strategiesFrequent dosingTreatment of opioid use disorderOpioid overdoseNovel dosing strategiesAlternative dosing strategiesCraving suppressionIncreased cravingEvidence of side effectsOpioid cravingShort-term safetyNaltrexone administrationIncreased dosing frequencyOpioid abstinenceNational opioid crisisRisk of opioid overdoseNaltrexoneExtended-releaseRisk patientsHigh-potencyPatient dose