2023
Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children
Kim J, Shimizu C, He M, Wang H, Hoffman H, Tremoulet A, Shyy J, Burns J. Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children. International Journal Of Molecular Sciences 2023, 24: 12318. PMID: 37569694, PMCID: PMC10418493, DOI: 10.3390/ijms241512318.Peer-Reviewed Original ResearchConceptsKawasaki diseaseEndothelial cellsCardiovascular outcomesInflammatory syndromeWeighted gene co-expression network analysisDifferent cardiovascular outcomesMultisystem inflammatory syndromePre-treatment serumEC homeostasisEndothelial-mesenchymal transitionCultured endothelial cellsPro-survival genesClinical manifestationsHealthy controlsImmune responseNFκB pathwayCell responsesEndothelial cell responsesDiseaseGene co-expression network analysisEC responseExpression levelsSyndromeCo-expression network analysisReduced transcripts
2022
An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease
Ghosh P, Katkar G, Shimizu C, Kim J, Khandelwal S, Tremoulet A, Kanegaye J, Bocchini J, Das S, Burns J, Sahoo D. An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nature Communications 2022, 13: 2687. PMID: 35577777, PMCID: PMC9110726, DOI: 10.1038/s41467-022-30357-w.Peer-Reviewed Original ResearchConceptsKawasaki diseaseHost immune responseLaboratory parametersImmune responseSARS-CoV-2 infectionInflammatory syndromeCytokine stormSerum cytokinesClinical featuresCytokine pathwaysCardiac phenotypeSyndromeGene signaturePediatric syndromesViral pandemicHeart tissueCOVID-19COVID-19 pandemicProximal pathwayDiseaseSeverityImmunopathogenesisPandemicCytokinesIllness