2022
Conserved meningeal lymphatic drainage circuits in mice and humans
Jacob L, de Brito Neto J, Lenck S, Corcy C, Benbelkacem F, Geraldo LH, Xu Y, Thomas JM, Kamouh M, Spajer M, Potier MC, Haik S, Kalamarides M, Stankoff B, Lehericy S, Eichmann A, Thomas JL. Conserved meningeal lymphatic drainage circuits in mice and humans. Journal Of Experimental Medicine 2022, 219: e20220035. PMID: 35776089, PMCID: PMC9253621, DOI: 10.1084/jem.20220035.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidVessel wall magnetic resonance imagingDural venous sinusesMagnetic resonance imagingCavernous sinusSystemic injectionImmune surveillanceVenous sinusesGlymphatic systemNeurological diseasesDura materVW-MRIResonance imagingBrain tissueEmissary veinsNeurological pathologiesAnterior partCSF outflowTracer injectionDrainage circuitThree-dimensional anatomyLymphatic vesselsPatientsDiagnostic toolSinus
2019
Anatomy and function of the vertebral column lymphatic network in mice
Jacob L, Boisserand LSB, Geraldo LHM, de Brito Neto J, Mathivet T, Antila S, Barka B, Xu Y, Thomas JM, Pestel J, Aigrot MS, Song E, Nurmi H, Lee S, Alitalo K, Renier N, Eichmann A, Thomas JL. Anatomy and function of the vertebral column lymphatic network in mice. Nature Communications 2019, 10: 4594. PMID: 31597914, PMCID: PMC6785564, DOI: 10.1038/s41467-019-12568-w.Peer-Reviewed Original ResearchConceptsLymphatic vesselsCentral nervous system immune responseFocal spinal cord lesionsT cell infiltrationSpinal cord lesionsSpinal cord injuryCNS immunityCord lesionsMeningeal lymphatic vesselsSympathetic gangliaCord injuryCell infiltrationSpinal cordInflammatory responseEpidural spaceThoracic ductImmune responseDura materSpinal tissuePotential targetVertebral tissuesLymphatic networkSpine segmentsTraditional histologyLittle information