2023
The historical progression of positron emission tomography research in neuroendocrinology
Bini J. The historical progression of positron emission tomography research in neuroendocrinology. Frontiers In Neuroendocrinology 2023, 70: 101081. PMID: 37423505, PMCID: PMC10530506, DOI: 10.1016/j.yfrne.2023.101081.Peer-Reviewed Original ResearchConceptsPositron emission tomographyPositron emission tomography researchEmission Tomography ImagingPositron emission tomography (PET) imagingNumber of radiopharmaceuticalsEndocrine organSystematic reviewEmission tomographyPET radioligandHormone actionTomography imagingPET imagingDifferent receptorsHuman brainPET researchImagingSystem actionsSteroidsCliniciansRadioligandHormoneBrainProgressionReceptors
2022
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Bini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo. Methods In Molecular Biology 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBeta-cell massFunctional beta-cell massDopamine D2/D3 receptorsD2/D3 receptorsBeta-cell lossType 2 diabetesEfficacy of therapeuticsQuantitative positron emission tomographyInsulin secretionDopamine receptorsD3 receptorsGlucose regulationPET radioligandEmission tomographyType 1Clinical usePET imagingReceptorsQuantitative PET imagingVMAT2Cellular transportersImagingVivoQuantitative imaging
2021
The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review
Bini J, Norcross M, Cheung M, Duffy A. The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review. Obesity Surgery 2021, 31: 4592-4606. PMID: 34304378, DOI: 10.1007/s11695-021-05576-7.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBariatric surgeryEmission tomographyBariatric surgery researchMalabsorption of foodBlood flowWhole-body PET imagingRadioligand developmentWeight lossPET imagingAmount of foodSurgery researchPhysiological effectsSurgeryPicomolar concentrationsTomographyRadioactive moleculesMetabolismMalabsorptionObesityPatientsFoodStomachPharmacologyReceptors
2020
Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study
Bini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study. Molecular Imaging And Biology 2020, 22: 1124-1131. PMID: 32133575, PMCID: PMC7351613, DOI: 10.1007/s11307-020-01490-z.Peer-Reviewed Original ResearchConceptsBody mass indexPositron emission tomographyDehydrogenase type 1Mass indexObese individualsEnzyme 11β-hydroxysteroid dehydrogenase type 1Whole brainType 1Higher body mass indexPositron emission tomography studyVT valuesSevere Alzheimer's diseaseEmission tomography studiesSteroid stress hormonesAge-associated increaseMean whole brainSignificant age-associated increaseRegional distribution volumesVisceral adiposityInsulin resistanceActive cortisolExcess cortisolInactive cortisoneMemory dysfunctionParietal lobe
2019
Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall
Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C. Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall. Bioconjugate Chemistry 2019, 31: 360-368. PMID: 31095372, PMCID: PMC7460274, DOI: 10.1021/acs.bioconjchem.9b00256.Peer-Reviewed Original ResearchConceptsAtherosclerotic vessel wallPositron emission tomographyVascular permeabilityVessel wallEmission tomographyRabbit atherosclerosis modelExperimental treatment optionsPET/magnetic resonance imagingDynamic contrast-enhanced MRIMultimodal positron emission tomographyContrast-enhanced MRIMagnetic resonance imagingDevelopment of nanotherapyNoninvasive imaging approachPET/MRIAtherosclerotic diseaseAtherosclerosis modelTreatment optionsAbdominal aortaIntravenous injectionAtherosclerotic lesionsResonance imagingPET/Treatment evaluationBiodistribution pattern
2016
In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models
Pérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models. JACC Cardiovascular Imaging 2016, 9: 950-961. PMID: 27236528, PMCID: PMC5589956, DOI: 10.1016/j.jcmg.2016.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisAutoradiographyDisease Models, AnimalFemaleFlow CytometryLipoproteins, HDLMagnetic Resonance ImagingMaleMice, Inbred C57BLMice, KnockoutMolecular ImagingOptical ImagingPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyPredictive Value of TestsRabbitsRadioisotopesRadiopharmaceuticalsReproducibility of ResultsTissue DistributionZirconiumConceptsHigh-density lipoproteinPositron emission tomographyHDL nanoparticlesPlaque macrophagesPET imagingAtherosclerotic plaque macrophagesRadioactivity uptake valuesIncident cardiovascular eventsCoronary heart diseaseDistinct pharmacokinetic profileStrong independent predictorHDL cholesterol concentrationsReverse cholesterol transportAdvanced atherosclerotic lesionsAccumulation of radioactivityMagnetic resonance imagingVivo PET imagingNoninvasive imaging toolNoninvasive PET imagingCardiovascular eventsIndependent predictorsAtherosclerosis modelHeart diseaseMurine modelAtherosclerotic lesions
2012
Radial k-space Acquisition Improves Robustness of MR-based Attenuation Maps for MR/PET Quantification in an Animal Imaging Study of the Abdomen
Bini J, Robson P, Calcagno C, Millon A, Lobatto M, Fayad Z. Radial k-space Acquisition Improves Robustness of MR-based Attenuation Maps for MR/PET Quantification in an Animal Imaging Study of the Abdomen. 2012, 1-6. DOI: 10.1109/spmb.2012.6469451.Peer-Reviewed Original ResearchMR/PET systemAttenuation mapRadial k-space acquisitionCartesian k-space trajectoriesReconstructed PET imagesAnimal imaging studiesK-space trajectoriesK-space acquisitionInterest-based comparisonPhoton attenuationPET systemPreclinical imagingAccurate segmentationPositron emission tomographyAttenuation correctionStandard segmentation algorithmsCartesian acquisitionExhibit artifactsPET quantificationQuantitative measurementsQuantitative positron emission tomography