2019
Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall
Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C. Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall. Bioconjugate Chemistry 2019, 31: 360-368. PMID: 31095372, PMCID: PMC7460274, DOI: 10.1021/acs.bioconjchem.9b00256.Peer-Reviewed Original ResearchConceptsAtherosclerotic vessel wallPositron emission tomographyVascular permeabilityVessel wallEmission tomographyRabbit atherosclerosis modelExperimental treatment optionsPET/magnetic resonance imagingDynamic contrast-enhanced MRIMultimodal positron emission tomographyContrast-enhanced MRIMagnetic resonance imagingDevelopment of nanotherapyNoninvasive imaging approachPET/MRIAtherosclerotic diseaseAtherosclerosis modelTreatment optionsAbdominal aortaIntravenous injectionAtherosclerotic lesionsResonance imagingPET/Treatment evaluationBiodistribution pattern
2013
Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner
Millon A, Dickson S, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, Ballet S, Robert P, de Castro J, Corot C, Fayad Z. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner. Atherosclerosis 2013, 228: 339-345. PMID: 23582588, PMCID: PMC4128694, DOI: 10.1016/j.atherosclerosis.2013.03.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, AbdominalAortic DiseasesAtherosclerosisAtorvastatinContrast MediaDextransDisease Models, AnimalDisease ProgressionFluorodeoxyglucose F18Heptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationMagnetic Resonance ImagingMagnetite NanoparticlesPlaque, AtheroscleroticPositron-Emission TomographyPredictive Value of TestsPyrrolesRabbitsRadiographyRadiopharmaceuticalsTime FactorsConceptsFDG-PETPlaque inflammationRegression groupAbdominal aortaAtherosclerotic rabbitsAortic wallMean standard uptake valueStrong FDG uptakeStandard uptake valueContrast-enhanced MRIFDG-PET dataFunctional imaging modalitiesProgression groupBaseline imagingFDG uptakeMR scannerSUVmean valuesUSPIO uptakeAtherosclerotic plaquesMacrophage densityUptake valueEarly changesInflammationRabbit modelDietary changes