2017
Causes of In-hospital and Post discharge Mortality Among Patients Hospitalized with Laboratory-Confirmed Influenza, Influenza Hospitalization Surveillance Network, 2014–2015
McGowan C, Arriola C, Cummings C, Kirley P, Miller L, Meek J, Anderson E, Monroe M, Bohm S, McMahon M, Bargsten M, Zansky S, Bennett N, Lung K, Thomas A, Schaffner W, Price A, Dos Santos Chaves S, Reed C, Garg S. Causes of In-hospital and Post discharge Mortality Among Patients Hospitalized with Laboratory-Confirmed Influenza, Influenza Hospitalization Surveillance Network, 2014–2015. Open Forum Infectious Diseases 2017, 4: s24-s24. PMCID: PMC5632265, DOI: 10.1093/ofid/ofx162.061.Peer-Reviewed Original ResearchLaboratory-confirmed influenzaCause of deathDeath certificatesInfluenza-related hospitalizationsPost-discharge mortalityDays post dischargeHalf of deathsIntensive care unitLocation of deathDeath registration systemInfluenza resultsHospital deathClinical characteristicsHospital dischargeIn-HospitalSymptom onsetInfluenza seasonCare unitRespiratory causesDischarge mortalitySeasonal influenzaVaccination ratesCardiovascular diseaseCommon causeHospitalization
2016
Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015
Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, Oni O, Ryan P, Eckel S, Lynfield R, Bargsten M, Zansky SM, Bennett N, Lung K, McDonald-Hamm C, Thomas A, Brady D, Lindegren ML, Schaffner W, Hill M, Garg S, Fry AM, Campbell AP. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015. Clinical Infectious Diseases 2016, 64: 364-367. PMID: 28013261, PMCID: PMC5480237, DOI: 10.1093/cid/ciw745.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiviral AgentsChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLength of StayLongitudinal StudiesMaleMiddle AgedOseltamivirPandemicsProspective StudiesRetrospective StudiesSeasonsUnited StatesYoung AdultBenefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza
Oboho I, Reed C, Gargiullo P, Leon M, Aragon D, Meek J, Anderson E, Ryan P, Lynfield R, Morin C, Bargsten M, Zansky S, Fowler B, Thomas A, Lindegren M, Schaffner W, Risk I, Finelli L, Chaves S. Benefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza. The Journal Of Infectious Diseases 2016, 214: 507-515. PMID: 26908745, DOI: 10.1093/infdis/jiw033.Peer-Reviewed Original ResearchConceptsInfluenza antiviral treatmentSevere influenzaAntiviral treatmentLength of stayPregnant womenEarly initiationInfluenza vaccinationIntensive care unit admissionAnnual influenza vaccinationCare unit admissionLaboratory-confirmed influenzaUnit admissionPregnancy trimesterPreterm deliveryRespiratory failurePulmonary embolismInfluenza seasonMedian ageSeverity strataMechanical ventilationParametric survival analysisIllness onsetInfant morbidityMedian lengthFetal loss
2015
Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008
Garg S, Jain S, Dawood FS, Jhung M, Pérez A, D’Mello T, Reingold A, Gershman K, Meek J, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L. Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008. BMC Infectious Diseases 2015, 15: 369. PMID: 26307108, PMCID: PMC4550040, DOI: 10.1186/s12879-015-1004-y.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionSeasonal influenza virus infectionICD-9-CM codesCertain underlying conditionsEmerging Infections ProgramCare unit admissionLaboratory-confirmed influenzaInfluenza virus infectionCause of deathCXR infiltrateUnit admissionICU admissionOlder patientsMechanical ventilationMultivariable analysisUnderlying conditionInfections ProgramChest radiographsVirus infectionPneumoniaSummary diagnosisInfectious diseasesInfluenzaPatientsAdultsObesity not associated with severity among hospitalized adults with seasonal influenza virus infection
Braun ES, Crawford FW, Desai MM, Meek J, Kirley PD, Miller L, Anderson EJ, Oni O, Ryan P, Lynfield R, Bargsten M, Bennett NM, Lung KL, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Chaves SS. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection 2015, 43: 569-575. PMID: 26148927, DOI: 10.1007/s15010-015-0802-x.Peer-Reviewed Original ResearchConceptsSeasonal influenza virus infectionMultivariate logistic regression modelSeasonal influenza severityLaboratory-confirmed influenzaRisk of pneumoniaInfluenza virus infectionLogistic regression modelsHospitalized adultsICU admissionObese patientsSevere obesityInfluenza severityArtificial ventilationVirus infectionWeight categoriesObesityPneumoniaSeverityRegression modelsAdultsUnderweightPatientsAdmissionInfectionInfluenzaDoes Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States
Arriola C, Anderson E, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren M, Lung K, Meek J, Mermel E, Miller L, Monroe M, Morin C, Oni O, Reingold A, Schaffner W, Thomas A, Zansky S, Finelli L, Chaves S. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States. The Journal Of Infectious Diseases 2015, 212: 1200-1208. PMID: 25821227, PMCID: PMC4683374, DOI: 10.1093/infdis/jiv200.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza severityDisease severityIntensive care unit admissionMultivariable logistic regression modelSevere influenza outcomesCare unit admissionLaboratory-confirmed influenzaMultivariable logistic regressionDiagnosis of pneumoniaLogistic regression modelsUnit admissionICU lengthVaccine effectivenessInfluenza seasonParametric survival modelsInfluenza outcomesVaccinated personsVaccinationPropensity scoreLogistic regressionOlder adultsPredominant strainSeverityInfluenza
2014
1341The benefit of early influenza antiviral treatment of pregnant women hospitalized with laboratory-confirmed influenza
Oboho I, Reed C, Leon M, Rothrock G, Aragon D, Meek J, Farley M, Ryan P, Peters S, Lynfield R, Morin C, Bargsten M, Zansky S, Fowler B, Thomas A, Mermel E, Lindegren M, Risk I, Finelli L, Chaves S. 1341The benefit of early influenza antiviral treatment of pregnant women hospitalized with laboratory-confirmed influenza. Open Forum Infectious Diseases 2014, 1: s58-s58. PMCID: PMC5781581, DOI: 10.1093/ofid/ofu051.158.Peer-Reviewed Original ResearchInfluenza antiviral treatmentLaboratory-confirmed influenzaAntiviral treatmentPregnant womenInfluenzaWomen
2012
Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original ResearchInfluenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Luckhaupt SE, Sweeney MH, Funk R, Calvert GM, Nowell M, D'Mello T, Reingold A, Meek J, Yousey-Hindes K, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Jones T. Influenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 556-562. PMID: 22469504, PMCID: PMC3309704, DOI: 10.3201/eid1804.110337.Peer-Reviewed Original Research
2011
Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
Vandermeer M, Thomas A, Kamimoto L, Reingold A, Gershman K, Meek J, Farley M, Ryan P, Lynfield R, Baumbach J, Schaffner W, Bennett N, Zansky S. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study. The Journal Of Infectious Diseases 2011, 205: 13-19. PMID: 22170954, DOI: 10.1093/infdis/jir695.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramLaboratory-confirmed influenzaInfluenza virus infectionVirus infectionPrevention's Emerging Infections ProgramMultivariable logistic regression modelInfluenza-related deathsChronic lung diseaseUse of statinsAdministration of statinsRisk of mortalityLogistic regression modelsProtective oddsHospitalized adultsInfluenza testsInfluenza vaccinationStatin useInfluenza seasonRenal diseaseAntiviral administrationImmunomodulatory effectsLung diseaseActive surveillanceInfections ProgramStatinsChildren With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009
Dawood F, Kamimoto L, D'Mello T, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett N, Thomas A, Schaffner W, Kirschke D, Finelli L. Children With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009. Pediatrics 2011, 128: e27-e32. PMID: 21646257, DOI: 10.1542/peds.2010-3343.Peer-Reviewed Original ResearchConceptsPandemic H1N1 influenzaAdditional medical conditionsAsthmatic childrenClinical courseInfluenza seasonH1N1 influenzaMedical conditionsLaboratory-confirmed influenzaAsthma exacerbationsRespiratory failureAsthma severityMedian ageInfluenza BInfluenza preventionIntensive careSeasonal influenzaMedical historyMedical recordsInfluenza AInfluenza typeAsthmaInfluenzaCare occurSubstantial proportionComplications
2010
Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008
Dawood FS, Fiore A, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L. Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008. The Pediatric Infectious Disease Journal 2010, 29: 585-590. PMID: 20589966, PMCID: PMC5856105, DOI: 10.1097/inf.0b013e3181d411c5.Peer-Reviewed Original ResearchConceptsInfluenza-associated pneumoniaChest radiographsHospitalized childrenIntensive care unit admissionCare unit admissionLaboratory-confirmed influenzaSevere clinical courseInfluenza complicationsUnit admissionRespiratory failureCommon complicationClinical courseInfluenza seasonTreatment strategiesPneumoniaMultivariate analysisNew pneumoniaGreater riskInfluenzaRadiographsAge 6Age 2HospitalizationAsthmaComplicationsBurden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008
Dawood FS, Fiore A, Kamimoto L, Bramley A, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Mueller M, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L, Network E. Burden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008. The Journal Of Pediatrics 2010, 157: 808-814. PMID: 20580018, DOI: 10.1016/j.jpeds.2010.05.012.Peer-Reviewed Original ResearchConceptsSevere outcomesInfluenza hospitalizationsHospitalization ratesHospitalized childrenEmerging Infections Program NetworkIntensive care unit admissionInfections Program NetworkSeasonal influenza hospitalizationsCare unit admissionLaboratory-confirmed influenzaPopulation-based surveillanceUnderlying medical conditionsHigher hospitalization ratesRate of hospitalizationProportion of childrenRapid diagnostic testsUnit admissionRespiratory failureBacterial coinfectionClinical courseHospital recordsSeasonal influenzaMedical historyDisease burdenIncidence rate