2011
Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome
Landau YE, Steinberg T, Richmand B, Leckman JF, Apter A. Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome. Journal Of Neural Transmission 2011, 119: 621-626. PMID: 22139323, PMCID: PMC3936959, DOI: 10.1007/s00702-011-0739-x.Peer-Reviewed Original ResearchConceptsTourette syndrome groupTourette syndromeSyndrome groupHealthy age-matched control subjectsTertiary pediatric medical centerAge-matched control subjectsIgG-4 levelsPediatric medical centerNovel therapeutic modalitiesNon-ceruloplasmin copperQuantitative immunoglobulinsImmunological markersControl subjectsHealthy childrenMedical recordsPhonic ticsMedical CenterTherapeutic modalitiesControl groupBiochemical markersSyndromeDemographic dataBiochemical indicesOxidative stressNeurodevelopmental disorders
2007
Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis
Yoon DY, Gause CD, Leckman JF, Singer HS. Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Journal Of The Neurological Sciences 2007, 255: 50-56. PMID: 17337006, DOI: 10.1016/j.jns.2007.01.069.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterReceptor densityPathophysiology of TSAlpha-adrenergic receptorsSex-matched controlsD2 receptor densityPostmortem brain tissueFrontal regionsDopaminergic dysfunctionNeurochemical abnormalitiesDopaminergic abnormalitiesNeurochemical markersTS patientsFrontal cortexSemiquantitative immunoblottingFrontal lobeBrain tissueTS subjectsTerminal markersOccipital regionAbnormalitiesVesicular dockingPathophysiologySyndrome
1995
Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex
Vaccarino F, Schwartz M, Hartigan D, Leckman J. Basic Fibroblast Growth Factor Increases the Number of Excitatory Neurons Containing Glutamate in the Cerebral Cortex. Cerebral Cortex 1995, 5: 64-78. PMID: 7719131, DOI: 10.1093/cercor/5.1.64.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorNerve growth factorGlutamate-containing neuronsCerebral cortexFibroblast growth factorGrowth factorAspartate-containing neuronsDifferent neurotransmitter phenotypesNumber of GABARatio of glutamateStem cellsNeurotransmitter phenotypeExcitatory neuronsInhibitory neuronsRat telencephalonVentricular zoneBFGF mRNAGABANeuronsCortexGlutamateDiffusible factorsThreefold increaseCellsFactors
1992
Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome.
Anderson GM, Pollak ES, Chatterjee D, Leckman JF, Riddle MA, Cohen DJ. Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome. Advances In Neurology 1992, 58: 123-33. PMID: 1414615.Peer-Reviewed Original Research
1983
Developmental and pharmacological aspects of attention deficit disorder (ADD).
Anderson GM, Shaywitz BA, Leckman JF, Hunt RD, Shaywitz SE, Cohen DJ. Developmental and pharmacological aspects of attention deficit disorder (ADD). Progress In Clinical And Biological Research 1983, 135: 207-23. PMID: 6364156.Peer-Reviewed Original Research