2018
Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial
Fatori D, de Bragança Pereira CA, Asbahr FR, Requena G, Alvarenga PG, de Mathis MA, Rohde LA, Leckman JF, March JS, Polanczyk GV, Miguel EC, Shavitt RG. Adaptive treatment strategies for children and adolescents with Obsessive-Compulsive Disorder: A sequential multiple assignment randomized trial. Journal Of Anxiety Disorders 2018, 58: 42-50. PMID: 30025255, DOI: 10.1016/j.janxdis.2018.07.002.Peer-Reviewed Original ResearchConceptsGroup cognitive behavioral therapySequential multiple assignmentTreatment failureInitial treatmentBaseline Yale-Brown ObsessiveChildhood OCDEffective initial treatmentProvision of treatmentCompulsive Scale scoresCognitive behavioral therapyAdaptive treatment strategiesYale-Brown ObsessiveSame regimenObsessive-compulsive disorderTreatment strategiesSymptom reductionPrimary analysisScale scoreFluoxetineTime pointsWeeksTreatmentChildrenEffect sizeTrials
2014
Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder
Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C, Leckman JF. Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive–compulsive disorder. Molecular Psychiatry 2014, 19: 1025-1030. PMID: 24912494, PMCID: PMC4169729, DOI: 10.1038/mp.2014.50.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment responseOCD patientsOdds ratioFurther treatment researchCase-control studyPoor treatment outcomesDifferential treatment responseSymptoms of OCDPrimary outcomeTreatment modalitiesEligible studiesTreatment outcomesPatientsElectronic searchSymptomsTotal participantsBehavioral therapyOCD treatmentDisordersSymptom dimensionsTreatment researchDSM-5Hoarding symptomsTreatment
2007
Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment
Rothenberger A, Roessner V, Banaschewski T, Leckman JF. Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment. European Child & Adolescent Psychiatry 2007, 16: 1-4. PMID: 17665277, DOI: 10.1007/s00787-007-1001-9.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderTic disordersTreatment of youthHyperactivity disorderCognitive disturbancesFuture researchOwn clinical entityDaily clinical practiceEvidence-based approachClinical entityDisordersTreatment choiceClinical practiceDifferential diagnosticsEssential research topicEndophenotypesYouthDifferent levelsTreatmentUnderstandingBetter understandingResearch topic
2005
Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment.
Swain JE, Leckman JF. Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment. Innov Clin Neurosci 2005, 2: 26-36. PMID: 21152158, PMCID: PMC3000195.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderNatural historyFirst-line optionCourse of illnessAlpha-adrenergic agentsComputerized literature searchAtypical neurolepticsTic disordersAccurate prognosticationAdrenergic agentsPathophysiological modelProper diagnosisHabit reversalSyndromeLiterature searchAnxiety disordersBehavioral interventionsImproved treatmentDisordersPatientsPractical reviewTreatmentDiagnosisAttention problems
2002
Tourette's syndrome
Leckman JF. Tourette's syndrome. The Lancet 2002, 360: 1577-1586. PMID: 12443611, DOI: 10.1016/s0140-6736(02)11526-1.Peer-Reviewed Original Research
1997
Fluoxetine Has No Marked Effect on Tic Symptoms in Patients with Tourette's Syndrome: A Double-Blind Placebo-Controlled Study
Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF. Fluoxetine Has No Marked Effect on Tic Symptoms in Patients with Tourette's Syndrome: A Double-Blind Placebo-Controlled Study. Journal Of Child And Adolescent Psychopharmacology 1997, 7: 75-85. PMID: 9334893, DOI: 10.1089/cap.1997.7.75.Peer-Reviewed Original ResearchConceptsTourette syndromeObsessive-compulsive symptomsObsessive-compulsive disorderPlacebo-controlled crossover trialTreatment of ticsWeeks of treatmentEfficacy of fluoxetineFluoxetine monotherapyFluoxetine treatmentCrossover trialObsessive-compulsive featuresAdditional subjectsFluoxetineSymptomsSignificant reductionSyndromeTreatmentSubjectsCrossover analysisMonotherapyPatientsMarked effectTrialsWeeks
1991
Clonidine Treatment of Gilles de la Tourette's Syndrome
Leckman JF, Hardin MT, Riddle MA, Stevenson J, Ort SI, Cohen DJ. Clonidine Treatment of Gilles de la Tourette's Syndrome. JAMA Psychiatry 1991, 48: 324-328. PMID: 2009034, DOI: 10.1001/archpsyc.1991.01810280040006.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLa Tourette's syndromeClonidine treatmentTourette syndromeTic severityDouble-blind clinical trialMotor tic severityClinical trialsClonidine hydrochlorideBehavioral symptomsClinical ratingsSyndromeMagnitude of responseClonidineTreatmentParent-rated measuresSeveritySubjectsPlaceboVideotaped interviewGroupSymptomsCliniciansHyperactivityTrials
1986
Gilles de la Tourette's syndrome: tics and central nervous system stimulants in twins and nontwins.
Price R, Leckman J, Pauls D, Cohen D, Kidd K. Gilles de la Tourette's syndrome: tics and central nervous system stimulants in twins and nontwins. Neurology 1986, 36: 232-7. PMID: 2868428, DOI: 10.1212/wnl.36.2.232.Peer-Reviewed Original Research